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Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A
Long non-coding RNAs play critical roles in the development of lung cancer by functioning as tumor suppressors or oncogenes. Changes in the...
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Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo
PurposeBerberine chloride (BBC) is a well-known plant isoquinoline alkaloid derived from Berberis aristata . In this study, we aim to explore the...
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Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response
Aims/hypothesisAlthough insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the...
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Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice
BackgroundStudies have shown that sperm-borne microRNAs (miRNAs) are involved in mammalian preimplantation embryonic development. In humans,...
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Prenatal Diagnosis for a Novel Missense Mutation in X-Linked Intellectual Disability Gene Followed by Favorable Pregnancy Outcome
Intellectual disability (ID) is still unexplained in 60% of cases and prenatal diagnosis is very challenging for this condition. A second gravida...
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Deciphering potential causative factors for undiagnosed Waardenburg syndrome through multi-data integration
BackgroundWaardenburg syndrome (WS) is a rare genetic disorder mainly characterized by hearing loss and pigmentary abnormalities. Currently, seven...
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Abolished clustering of MeCP2T158M can be partially reverted with small molecules
Rett syndrome (OMIM 312750) is a rare neurodevelopmental disorder caused by de novo mutations in the Methyl-CpG Binding Protein 2 (MeCP2) gene...
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Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
BackgroundGenome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the...
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hsa-mir-(4328, 4422, 548z and -628-5p) in diabetic retinopathy: diagnosis, prediction and linking a new therapeutic target
AimsGrowing evidence suggests that microRNAs (miRNAs) are crucial in controlling how diabetic retinopathy (DR) develops. We intend to mine miRNAs...
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Alveolar Epithelial Type 2 Cell Dysfunction in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible pulmonary interstitial disease that seriously affects the patient’s quality of...
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Retrospective evaluation of neonates with fatal congenital lung malformation: A single center 15-year forensic autopsy experience
Congenital lung malformation (CLM) is a leading cause of infant mortality. Clinical methods for diagnosing CLM mainly rely on computed tomography,...
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Proteomic analysis implicates that postovulatory aging leads to aberrant gene expression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes
BackgroundIn mammals, oocytes display compromised quality after experiencing a process of postovulatory aging. However, the mechanisms underlying are...
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A genetic profiling guideline to support diagnosis and clinical management of lymphomas
The new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization...
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Genome-wide transcriptomics of the amygdala reveals similar oligodendrocyte-related responses to acute and chronic alcohol drinking in female mice
Repeated excessive alcohol consumption is a risk factor for alcohol use disorder (AUD). Although AUD has been more common in men than women, women...
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Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature
Breast cancer is a significant and deadly threat to women globally. Moreover, Breast cancer metastasis is a complicated process involving multiple...
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Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent...
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Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis
BackgroundRecent studies have uncovered that the aberrant expression of LINC00665 contributes to the malignant pathological process of various...
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Investigation of shared genetic features and related mechanisms between diabetes and tuberculosis
ObjectiveThis study aimed to integrate bioinformatics technology to explore shared hub genes and related mechanisms between diabetes and tuberculosis...
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Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis
Morphogenesis and organogenesis in the low organisms have been found to be modulated by a number of proteins, and one of such factor, deformed...
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TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC)...
