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Association between selective digestive decontamination and decreased rate of acquired candidemia in mechanically ventilated ICU patients: a multicenter nationwide study
BackgroundCandidemia is a high-risk complication among intensive care unit (ICU) patients. While selective digestive decontamination (SDD) has been...
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Selective decontamination of the digestive tract in colorectal surgery reduces anastomotic leakage and costs: a propensity score analysis
PurposeAnastomotic leakage (AL) and surgical site infection (SSI) account for most postoperative complications in colorectal surgery. The aim of this...
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Selective digestive decontamination, a seemingly effective regimen with individual benefit or a flawed concept with population harm?
Selective digestive decontamination (SDD) regimens, variously constituted with topical antibiotic prophylaxis (TAP) and protocolized parenteral...
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Intestinal Microbiota in Sepsis
Sepsis is defined as a life-threatening organ dysfunction, which is caused by a dysregulated host response to infection. The composition of the...
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Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review
Selective decontamination of the digestive tract (SDD) is an infection prevention measure for intensive care unit (ICU) patients that was proposed...
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Antibiotic use in acute mesenteric ischemia: a review of the evidence and call to action
Acute mesenteric ischemia (AMI) is a life-threatening condition with a high mortality rate. The standard practice after making the diagnosis includes...
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Prevention of anastomotic leak in rectal cancer surgery with local antibiotic decontamination: a prospective, randomized, double-blind, placebo-controlled single center trial
PurposeAnastomotic leak and other infectious complications are septic complications of rectal cancer surgery caused by bacteria. Data from registry...
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Carriage of antibiotic-resistant Gram-negative bacteria after discontinuation of selective decontamination of the digestive tract (SDD) or selective oropharyngeal decontamination (SOD)
BackgroundSelective decontamination of the digestive tract (SDD) and selective oropharyngeal decontamination (SOD) reduce colonization with...
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Small intestinal bacterial overgrowth as a cause of protracted wound healing and vitamin D deficiency in a spinal cord injured patient with a sacral pressure sore: a case report
BackgroundPressure sores are sometimes refractory to treatment, often due to malnutrition. Small intestinal bacterial overgrowth (SIBO) obstructs...
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Structural equation modelling the relationship between anti-fungal prophylaxis and Pseudomonas bacteremia in ICU patients
PurposeAnimal models implicate candida colonization facilitating invasive bacterial infections. The clinical relevance of this microbial interaction...
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Modelling and Simulation of the Effect of Targeted Decolonisation on Incidence of Extended-Spectrum Beta-Lactamase-Producing Enterobacterales Bloodstream Infections in Haematological Patients
IntroductionHaematological patients are at higher risk of bloodstream infections (BSI) after chemotherapy. The aim of this study was to develop a...
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The ecological effects of selective decontamination of the digestive tract (SDD) on antimicrobial resistance: a 21-year longitudinal single-centre study
BackgroundThe long-term ecological effects on the emergence of antimicrobial resistance at the ICU level during selective decontamination of the...
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Mechanical bowel preparation combined with oral antibiotics reduces infectious complications and anastomotic leak in elective colorectal surgery: a pooled-analysis with trial sequential analysis
ObjectiveA pooled analysis combined with trial sequential analysis (TSA) was conducted in order to explore the effect of mechanical bowel preparation...
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Candida and the Gram-positive trio: testing the vibe in the ICU patient microbiome using structural equation modelling of literature derived data
BackgroundWhether Candida interacts with Gram-positive bacteria, such as Staphylococcus aureus, coagulase negative Staphylococci (CNS) and Enterococci,...
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Multidrug-resistant bacterial infections in the liver transplant setting
Bacterial infections pose a life-threatening complication in patients with decompensated liver cirrhosis and acute-on-chronic liver failure. An...
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Gut Microbiota Modulation: Implications for Infection Control and Antimicrobial Stewardship
The human microbiome comprises a complex ecosystem of microbial communities that exist within the human body, the largest and most diverse of which...