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eTFC-01: a dual-labeled chelate-bridged tracer for SSTR2-positive tumors
BackgroundIntegrating radioactive and optical imaging techniques can facilitate the prognosis and surgical guidance for cancer patients. Using a...
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CT-based nomogram development and validation to predict SSTR2, VEGFR2 and MGMT expression for pancreatic neuroendocrine neoplasms
ObjectivesTo establish and validate a model to predict somatostatin receptor 2 (SSTR2), vascular endothelial growth factor receptor 2 (VEGFR2) and O 6 ...
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SSTR2 Expression in Olfactory Neuroblastoma: Clinical and Therapeutic Implications
Somatostatin receptor 2 (SSTR2) expression has previously been documented in olfactory neuroblastoma (ONB). Here, we fully characterize SSTR2...
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A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2
BackgroundNo universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of...
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Immunohistochemical Expression Pattern of Theragnostic Targets SSTR2 and PSMA in Endolymphatic Sac Tumors: A Single Institution Case Series
BackgroundEndolymphatic sac tumors are rare neoplasia characterized by slow growth. However, their clinical impact should not be underestimated,...
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Immunological signatures and predictive biomarkers for first-generation somatostatin receptor ligand resistance in Acromegaly
PurposePredicting resistance to first-generation Somatostatin Receptor Ligands (fg-SRL) in Acromegaly patients remains an ongong challenge....
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Structural modifications toward improved lead-203/lead-212 peptide-based image-guided alpha-particle radiopharmaceutical therapies for neuroendocrine tumors
PurposeThe lead-203 ( 203 Pb)/lead-212 ( 212 Pb) elementally identical radionuclide pair has gained significant interest in the field of image-guided...
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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized by increased bone...
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Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study
PurposeTo correlate somatostatin receptor (SSTR) and proliferative activity profile (SSTR2, SSTR5, Ki-67) at immunohistochemistry (IHC) with...
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The usefulness of [68 Ga]Ga-DOTA-JR11 PET/CT in patients with meningioma: comparison with MRI
PurposeClinical studies of PET imaging using SSTR2 agonists have demonstrated high accuracy and correlation with SSTR2 expression in meningiomas....
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Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland
BackgroundLymphoepithelial carcinoma of the salivary glands (LECSG) is a rare disease in the Western hemisphere that is typically associated with an...
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First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs
BackgroundThe [ 177 Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to...
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Somatostatin receptor imaging with [68Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma
PurposeTo explore the feasibility of [ 68 Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with non-keratinizing...
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Quantitative digital image analysis of somatostatin receptor 2 immunohistochemistry in pancreatic neuroendocrine tumors
Immunohistochemical analysis of somatostatin receptor 2 (SSTR2) provides important information regarding the potential therapeutic efficacy of...
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Direct effects of octreotide on osteoblast cell proliferation and function
PurposeOctreotide (OCT) is a first-generation somatostatin analog (SSA) used in the treatment of acromegaly and neuroendocrine tumors (NETs). In both...
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[68 Ga]-DOTATATE PET/MR-based evaluation of physiologic somatostatin receptor 2 expression in the adult pituitary gland as a function of age and sex in a prospective cohort
PurposeThe pituitary gland has the fourth highest physiologic avidity of [68 Ga]-DOTATATE. In order to guide our understanding of [68 Ga]-DOTATATE...
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A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors
BackgroundPhysiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at...
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The potential of somatostatin receptor 2 as a novel therapeutic target in salivary gland malignant tumors
BackgroundTreatment regimens for patients with metastatic or recurrent post-radiation, locoregional, unresectable salivary cancer are limited. An...
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Suspicious cold thyroid nodule with intense focal 68Ga-DOTATATE uptake: a case report
A 51-year-old male was found with bilateral thyroid nodules on ultrasonography neck imaging. The largest nodule, measuring 23 × 26 × 35 mm, was...
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Drug Development in Neuroendocrine Tumors: What Is on the Horizon?
Neuroendocrine neoplasms (NENs) constitute a heterogenous group of malignancies. Translational research into NEN cell biology is the cornerstone for...
