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Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy by deubiquitinating Smad7
BackgroundSalvianolic acid B (Sal B), a water-soluble phenolic compound derived from Salvia miltiorrhiza Bunge, is commonly used in Traditional...
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Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus
PurposeGenome-wide association studies have identified SMAD7 as a colorectal cancer (CRC) susceptibility gene. However, its underlying mechanism has...
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Mir-195-5p targets Smad7 regulation of the Wnt/β-catenin pathway to promote osteogenic differentiation of vascular smooth muscle cells
In this study, we sought to investigate the mechanisms of action of miR-195-5p in the osteogenic differentiation of vascular smooth muscle cells...
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The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7
Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential biomarker of atherosclerosis. Standardized diagnostic tests...
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Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein
PurposeTumor metastasis is the main cause of death from breast cancer patients and cell migration plays a critical role in cancer metastasis. Recent...
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miR-92a-3p-inspired shRNA exhibits pro-chondrogenic and chondrocyte protective effects in osteoarthritis treatment through targeting SMAD6/7
IntroductionOsteoarthritis (OA) compromises patients’ quality of life and requires further study. Although miR-92a-3p was reported to possess...
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Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling
Glioblastoma (GBM) is the most aggressive primary brain tumor as one of the deadliest cancers. The TGF-β signaling acts as an oncogenic factor in...
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Ursodeoxycholic acid ameliorates erectile dysfunction and corporal fibrosis in diabetic rats by inhibiting the TGF-β1/Smad2 pathway
Corporal tissue fibrosis is critical in diabetes-associated erectile dysfunction. Transforming growth factor-β1/Small mothers against...
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N-acetylcysteine regulates oxalate induced injury of renal tubular epithelial cells through CDKN2B/TGF-β/SMAD axis
This study was aimed to investigate the preventive effects of N -acetyl- l -cysteine (NAC) against renal tubular cell injury induced by oxalate and...
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Exosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells
BackgroundHeterotopic ossification (HO) can limit joint activity, causes ankylosis and impairs the function and rehabilitation of patients....
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Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway
ObjectiveTo explore the effect and mechanism of Dahuang Zhechong Pill (DHZCP) on liver fibrosis.
MethodsLiver fibrosis cell model was induced by...
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Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathy
BackgroundDiabetic nephropathy (DN) is the major cause of kidney failure, and glomerular podocytes play critical roles in the pathogenesis of DN by...
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OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor
Ovo-like transcriptional repressor 1 (OVOL1) is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition (MET). The...
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Up-regulation of CREB-1 regulates tendon adhesion in the injury tendon healing through the CREB-1/TGF-β3 signaling pathway
AimTo explore the mechanism of the healing of tendon tissue and anti-adhesion, and to discuss the role of the transforming growth factor-β3...
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The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway
BackgroundHepatic fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) which is mainly secreted by activated hepatic...
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Imbalance in the estrogen/androgen ratio may affect prostate fibrosis through the TGF-β/Smad signaling pathway
ObjectiveThe present study aimed to investigate the effects of an imbalance in the estrogen/androgen ratio on prostate fibrosis.
Methods ...
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Differential expression of microRNAs targeting genes associated with the development of high-grade gliomas
BackgroundHighly malignant high-grade gliomas are tumors of the central nervous system (CNS). They are solid tumors arising from transformed cells of...
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TGF-β3 regulates adhesion formation through the JNK/c-Jun pathway during flexor tendon healing
BackgroundThe injured flexor tendon has poor healing ability, which is easy to cause tendon adhesion. It can affect the recovery of tendon function,...
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Buyang Huanwu Decoction protects against STZ-induced diabetic nephropathy by inhibiting TGF-β/Smad3 signaling-mediated renal fibrosis and inflammation
BackgroundBuyang Huanwu Decoction (BHD) is a classical Chinese Medicine formula empirically used for diabetic nephropathy (DN). However, its...
