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Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway
ObjectiveTo investigate the mechanism of induction of ferroptosis by brazilin in breast cancer cells.
MethodsBreast cancer 4T1 cells were divided...
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Tetrandrine citrate suppresses lung adenocarcinoma growth via SLC7A11/GPX4-mediated ferroptosis
Ferroptosis is a mode of programmed cell death that plays a crucial role in tumor biology processes. Although tetrandrine citrate (TetC) has been...
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Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
BackgroundFerroptosis is a new form of nonapoptotic and iron-dependent type of cell death. Glutathione peroxidase-4 (GPX4) plays an essential role in...
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Reduction of SLC7A11 and GPX4 Contributing to Ferroptosis in Sperm from Asthenozoospermia Individuals
Ferroptosis is a newly defined form of regulated cell death, which is involved in various pathophysiological conditions. However, the role of...
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Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss
PurposeThe purpose of our study is to investigate the function of YAP1 in the trophoblast ferroptosis and maternal-fetal interface communication of...
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Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53
BackgroundDiabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate...
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Exosomes derived from BMSCs enhance diabetic wound healing through circ-Snhg11 delivery
BackgroundExosomes (Exos) generated from bone mesenchymal stem cells (BMSCs) are elucidated to enhance cutaneous wound healing in mice models of...
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Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11
BackgroundOsteoarthritis (OA) is a common disease with a complex pathology. This study aimed to investigate the correlation between the aberrant...
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Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11
BackgroundLuteolin (3,4,5,7-tetrahydroxy flavone) is reported to strongly protect from acute carbon tetrachloride (CCl 4 ) -induced liver injury or...
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Ferroptosis is an effective strategy for cancer therapy
Ferroptosis is a form of intracellular iron-dependent cell death that differs from necrosis, autophagy and apoptosis. Intracellular iron mediates...
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Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis
Autism spectrum disorder (ASD) is a complicated, neurodevelopmental disorder characterized by social deficits and stereotyped behaviors. Accumulating...
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A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis
Ferroptosis is a non-apoptotic form of regulated cell death characterized by iron-dependent lipid peroxidation. It can be triggered by various...
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Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway
ObjectivesTo investigate whether ferroptosis is involved in HCY-induced endothelial injury and the possible mechanism of HCY-induced ferroptosis.
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Fanconi anemia complementation group D2 promotes sensitivity of endometrial cancer cells to chemotherapeutic agents by inhibiting the ferroptosis pathway
BackgroundResistance can develop during treatment of advanced endometrial cancer (EC), leading to unsatisfactory results. Fanconi anemia...
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25-hydroxyvitamin D3 inhibits oxidative stress and ferroptosis in retinal microvascular endothelial cells induced by high glucose through down-regulation of miR-93
BackgroundThe decrease of vitamin D plays a critical role in diabetes mellitus (DM)-induced oxidative stress and vascular endothelial injury....
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Ferroptosis-related signature and immune infiltration characterization in acute lung injury/acute respiratory distress syndrome
BackgroundAcute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the most life-threatening diseases in the intensive care unit...
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1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells
PurposeHyperandrogenism, one of the most frequent causes of anovulation in women, increases the risk of metabolic disorders in patients with...
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Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
BackgroundCurdione is a sesquiterpene isolated from Curcumae Rhizoma that possesses high biological activity and extensive pharmacological effects....
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Ginsenoside compound K induces ferroptosis via the FOXO pathway in liver cancer cells
Liver cancer is a common malignant tumor worldwide, traditional Chinese medicine is one of the treatment measures for liver cancer because of its...
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Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids
BackgroundGegen Qinlian decoction (GQD) is a classic prescription for treating ulcerative colitis (UC) in traditional Chinese medicine. However, the...
