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New drugs in the treatment of acute myeloid leukaemia
Purpose of reviewIn the past few years, research in the underlying pathogenic mechanisms of acute myeloid leukaemia (AML) has led to challenging...
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Tc-99m-N-MPO: Novel cationic Tc-99m radiotracer for myocardial perfusion imaging
Background . Technetium 99m-N-MPO ([Tc-99m-N(mpo)(PNP5)] + ) is a cationic Tc-99m nitrido complex. The objective of this study is to evaluate its...
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Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice
PurposePreviously, we studied the effect of co-administration of paclitaxel with the second generation ABCB1 (p-gp) modulator valspodar on the...
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Expressions and clinicopathologic significance of five heat shock proteins in esophageal squamous cell carcinoma
ObjectiveTo investigate the expressions of heat shock protein (hsp) 10, hsp27, hsp60, hsp70 and hsp90α in esophageal squamous cell carcinoma (ESCC)...
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Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)
The importance of P-glycoprotein (P-gp) in the pharmacokinetics of amisulpride and the effects of a P-gp inhibitor cyclosporine A (CsA) was...
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cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance
cDNA microarray analysis is a highly useful tool for the classification of tumors and for prediction of patient prognosis to specific cancers based...
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Effect of amifostine on the cytotoxicity of daunorubicin and daunoxome in tumor and normal cells
Anthracyclines are powerful cytotoxic agents, used as first-line treatment of leukemias and many other tumors, but host-tissue toxicity is their main...
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Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice
Purpose : To evaluate the pharmacological properties and the possible therapeutic applications of a series of synthetic marine natural product...
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Positron Emission Tomography Studies on Binding of Central Nervous System Drugs and P-Glycoprotein Function in the Rodent Brain
The permeability of the blood–brain barrier (BBB) is one of the factors determining the bioavailability of drugs in the brain. The BBB only allows...
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Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice
P-glycoprotein inhibitors can increase the oral bioavailability of paclitaxel. We have now explored the mechanisms that determine the efficacy of...
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Pharmacokinetics and neutrophil toxicity of paclitaxel orally administered in mice with recombinant interleukin-2
PurposeIntrinsic P-glycoprotein (P-gp) expression in the gut limits paclitaxel uptake and, thus, its bioavailability when administered orally....
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Cross-Resistance Studies of Isogenic Drug-Resistant Breast Tumor Cell Lines Support Recent Clinical Evidence Suggesting that Sensitivity to Paclitaxel may be Strongly Compromised by Prior Doxorubicin Exposure
Less than half of breast cancer patients respond to second-line chemotherapy with paclitaxel after failing treatment with anthracyclines such as...
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Experimental study on the preventive mechanism of salviae miltiorrhizae against atherosclerosis in rabbits models
The preventive mechanism of salviae miltiorrhizae (SM) against experimental atherosclerosis (AS) in rabbits models was investigated. The experimental...
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Effect of valspodar on the pharmacokinetics of unbound paclitaxel
The aim of this multicenter study was to determine whether valspodar (Amdray™; code designation, SDZ PSC 833), a potent P-glycoprotein (P-gp)...
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Potent Killing of Paclitaxel- and Doxorubicin-resistant Breast Cancer Cells by Calphostin C Accompanied by Cytoplasmic Vacuolization
Drug resistance is a major impediment to the successful treatment of breast cancer using chemotherapy. The photoactivatable drug calphostin C has...
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The cyclosporin PSC 833 increases survival and delays engraftment of human multidrug-resistant leukemia cells in xenotransplanted NOD-SCID mice
Circumvention of chemoresistance in cancer may involve several modulator drugs with high affinity for the multidrug transporter P-glycoprotein (Pgp),...
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A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)
Abstract
Purpose. To develop a population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of zosuquidar.3HCl, a potent...
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Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts
Abstract
Purpose. We have recently identified a deoxycytidine nucleoside analogue, troxacitabine (β- L -dioxolane cytidine, Troxatyl; Shire BioChem),...
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P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel
Purpose: Recent studies in humans and mice have demonstrated that intestinal P-glycoprotein plays a causative role in the limited absorption of...