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A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect
BackgroundPigment epithelial-derived factor (PEDF), a 50 kDa secreted glycoprotein, exhibits distinct effects on a range of cell types. PEDF has been...
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WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes
Wnt-1 inducible signaling pathway protein 2 (WISP-2/CCN5) is a recently identified adipokine that has been described as an important mediator of...
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High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1
ObjectiveBladder outlet obstruction (BOO) results in significant fibrosis in the chronic stage and elevated bladder pressure. Piezo1 is a type of...
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VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells
BackgroundAlternative splicing of Vascular endothelial growth factor-A mRNA transcripts (commonly referred as VEGF) leads to the generation of...
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Repetitive restriction of muscle blood flow enhances mTOR signaling pathways in a rat model
Skeletal muscle is a plastic organ that adapts its mass to various stresses by affecting pathways that regulate protein synthesis and degradation....
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Growing burden of diabetes in Pakistan and the possible role of arsenic and pesticides
This review is undertaken to address the possible role of arsenic and pesticides in the prevalence of diabetes in Pakistan and to highlight a...
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Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine trachea cells, alveolar macrophages, and precision-cut lung slices
Viral respiratory diseases remain of major importance in swine breeding units. Swine influenza virus (SIV) is one of the main known contributors to...
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Anti-vascular endothelial growth factor therapy in the era of personalized medicine
PurposeTo review the role of anti-vascular endothelial growth factor (anti-VEGF) therapies in the personalized medicine era.
MethodsWe searched...
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Activation of mitogen- and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins
Growth of breast cancers is often dependent on ovarian steroid hormones making the tumors responsive to antagonists of hormone receptors. However,...
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Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth
Serum-and-glucocorticoid-inducible-kinase-1 (SGK1) is under regulation of several hormones, mediators and cell stressors. More specifically, SGK1...
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Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases
The continuous production and efflux of reactive oxygen/nitrogen species from endogenous and exogenous sources can damage biological molecules and...
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Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
Aims/hypothesisChronic hyperglycaemia aggravates insulin resistance, at least in part, by increasing the formation of advanced glycation end-products...
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Eicosapentaenoic acid inhibits endothelial cell migration in vitro
BackgroundAs n -3 Polyunsaturated Fatty Acids exert a beneficial action on the cardiovascular system, it is important to investigate their effects on...
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Biomechanical regulation of cell orientation and fate
Biomechanical regulation of tumor phenotypes have been noted for several decades, yet the function of mechanics in the co-evolution of the tumor...
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Effects of insulin and free fatty acids on matrix metalloproteinases
To investigate if increased activation of matrix metalloproteinases (MMPs) may contribute to the large cardiovascular risk associated with...
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Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor -induced cell migration
The aim of this study was to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cell migration induced by platelet-derived growth...
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Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly
Angiogenesis, the growth of new capillaries from pre-existing ones, occurs through dynamic functions of the endothelial cells (EC), including...
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STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
Classical Hodgkin lymphoma (cHL) is a distinct malignancy of the immune system. Despite the progress made in the understanding of the biology of cHL,...
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P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation
Cyclin D3 plays a critical role in maturation of precursor T cells and their levels are tightly regulated during this process. Alteration of cyclin...
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Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38
Activation of the tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) by VEGF leads to the activation of stress-activated...
