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Proportions and risk factors of chronic obstructive pulmonary disease and preserved ratio impaired spirometry, and association with small airway disease, in the positive screening older population from China: a cross-sectional study
BackgroundEarly diagnosing Chronic Obstructive Pulmonary Disease (COPD) is relatively difficult. Therefore, the concepts of preserved ratio impaired...
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Anthropometric estimators of abdominal fat volume in adults with overweight and obesity
Background/ObjectivesTo evaluate anthropometric measures for the prediction of whole-abdominal adipose tissue volumes V XAT (subcutaneous V SAT ,...
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Evaluation of the relationship between abdominal fat distribution and osteoporotic vertebral compression fracture with MRI
ObjectiveThis study was carried out to investigate the effects of abdominal subcutaneous adiposity and visceral adiposity on osteoporotic compression...
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Stapokibart in Healthy Volunteers and Adult Subjects with Atopic Dermatitis
IntroductionStapokibart, a novel humanized anti-interleukin (IL)-4 receptor alpha monoclonal antibody, inhibits the signaling of IL-4 and IL-13,...
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Serum triglyceride glucose index is a valuable predictor for visceral obesity in patients with type 2 diabetes: a cross-sectional study
BackgroundSince the triglyceride glucose (TyG) index can reflect insulin resistance, it has been proven to be an efficient predictor of...
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Effect of Opioid-Free General Anesthesia Versus Opioid-Based General Anesthesia on Postoperative Pain and Immune Response in Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Trial
Perioperative opioids are associated with several adverse effects including nausea, vomiting, and long-term addiction. Opioid-free anesthesia may...
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Relationship between sacral-abdominal wall distance, movement performance, and spinal alignment in osteoporosis: a retrospective study
BackgroundAging is associated with muscle atrophy, as typified by sarcopenia. Loss of abdominal muscle strength can cause abdominal wall laxity. The...
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Trends in the relationship between suicide behaviors and obesity among adolescents in the United States from 1999 to 2019
Previous studies indicate that obesity is a risk factor of suicide behaviors among adolescents. Whether this association has remained consistent...
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Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study
BackgroundAD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing...
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Relationship between airway inflammation, small airway dysfunction, and frequency of acute exacerbations in patients with chronic obstructive pulmonary disease
ContextRecurrent exacerbations in COPD patients are associated with accelerated reduction in lung function. Airway inflammation and small airway...
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Application of impulse oscillometry to detect interstitial lung disease and airway disease in adults with rheumatoid arthritis
BackgroundWe conducted a retrospective observational study to explore the potential application of impulse oscillometry (IOS) as an alternative to...
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Identification and treatment of persistent small airway dysfunction in paediatric patients with asthma: a retrospective cohort study
BackgroundAsthma is a common respiratory disease. In asthma, the small airways have more intensive inflammation and prominent airway remodelling,...
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Associations between short-term exposure to ambient air pollution and lung function in adults
BackgroundEvidence of the acute effects of high-level air pollution on small airway function and systemic inflammation in adults is scarce.
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The role of small airway function parameters in preschool asthmatic children
BackgroundSmall airways are the major sites of inflammation and airway remodeling in all severities of asthma patients. However, whether small airway...
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Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD
BackgroundParameters from maximal expiratory flow-volume curves (MEFVC) have been linked to CT-based parameters of COPD. However, the association...
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Human Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC42, a Novel Farnesoid X Receptor Agonist
BackgroundASC42 is a non-steroidal farnesoid X receptor agonist currently in clinical development for chronic liver diseases, such as nonalcoholic...
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Advances in airway management in recent 10 years from 2013 to 2023
Difficult airway management has been the focus in the field of anesthesiology. Clinical research in difficult airway management has made some...
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Investigating the Physical and Mental Health Nexus: a Network Analysis of Depression, Cardiometabolic Health, Bone Mass, and Perceived Health Status Among Filipino Domestic Workers
BackgroundMigrant domestic workers are vulnerable to physical and mental health problems given the many challenges they experience while working...
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Validity and reliability of the Persian version of the machiavellian personality scale and its association with social adjustment and risky behaviors in Iranian college students
ObjectiveThe present study aims to develop and assess the psychometric properties of the Persian version of the Machiavellian Personality Scale...
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Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Novel Recombination Human Nerve Growth Factor in Healthy Chinese Subjects
BackgroundNerve growth factor (NGF), the first-discovered member of the neurotrophin family, has long been regarded as a potential drug to combat...
