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Using the ‘Leapfrog’ Design as a Simple Form of Adaptive Platform Trial to Develop, Test, and Implement Treatment Personalization Methods in Routine Practice
The route for the development, evaluation and dissemination of personalized psychological therapies is complex and challenging. In particular, the...
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ASO Author Reflections: High-Intensity Focused Ultrasound will Become the Routine Practice for Treatment of Localized Prostate Cancer
PastMost prostate cancers are slow growing and are often diagnosed at an old age, which may result in treatment never being needed. However,...
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Intravitreal Aflibercept for the Treatment of Diabetic Macular Edema in Routine Clinical Practice: Results from the 24-Month AURIGA Observational Study
IntroductionAURIGA is the largest real-world study to date to evaluate intravitreal aflibercept (IVT-AFL) in the treatment of diabetic macular edema...
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Prevalence and prediction of dropout during depression treatment in routine outpatient care: an observational study
Efficacious treatments are available for major depressive disorder (MDD), but treatment dropout is common and decreases their effectiveness. However,...
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Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data
Study questionThe objective was to construct a model for predicting the probability of recurrent implantation failure (RIF) after assisted...
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Certolizumab Pegol for the Treatment of Plaque Psoriasis in Routine Clinical Practice: One-Year Results from the CIMREAL Study
IntroductionCertolizumab pegol (CZP) is an anti-tumor necrosis factor alpha (TNFα) approved for the treatment of moderate to severe plaque psoriasis...
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Impact of anti-VEGF treatment on development of proliferative diabetic retinopathy in routine clinical practice
BackgroundThis study evaluated impact of anti–vascular endothelial growth factor (VEGF) treatment on proliferative diabetic retinopathy (PDR)...
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A randomized controlled double-blinded split-face prospective clinical trial to assess the efficacy, safety, and tolerability of a novel 3-step routine compared to benzoyl peroxide for the treatment of mild to moderate acne vulgaris
Adult acne vulgaris affects up to 43–51% of individuals. While there are numerous treatment options for acne including topical, oral, and...
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Treatment demand for cannabis use problems: analyses of routine data from 30 European countries
Cannabis use and treatment demand has risen in the past decade. Previous analyses of treatment demand are limited by methodological constraints or...
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The effect of movement system impairment-based classification treatment compared to routine physiotherapy on pain, disability, alignment, and movement impairments in individuals with tibiofemoral rotation syndrome: a randomized controlled trial
BackgroundKnee pain is a common musculoskeletal problem. Lower extremity movement impairments could alter stresses in different planes and contribute...
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Effectiveness of Blended Cognitive Behavioral Therapy Versus Treatment as Usual for Depression in Routine Specialized Mental Healthcare: E-COMPARED Trial in the Netherlands
BackgroundThe general aim of this study was to investigate the effectiveness of blended Cognitive Behavioral Therapy (bCBT) as compared to Treatment...
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Implementing the Patient Needs in Asthma Treatment (NEAT) questionnaire in routine care: a qualitative study among patients and health professionals
BackgroundMany patients with asthma report unmet health care needs. The Patient Needs in Asthma Treatment (NEAT) questionnaire is a validated...
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Intravitreal aflibercept for the treatment of patients with neovascular age-related macular degeneration in routine clinical practice in Latin America: the AQUILA study
BackgroundAQUILA (NCT03470103) was a prospective, observational, 12-month cohort study evaluating treatment patterns, clinical effectiveness, and...
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Intravitreal aflibercept for the treatment of patients with diabetic macular edema in routine clinical practice in Latin America: the AQUILA study
BackgroundAQUILA (NCT03470103) was a prospective, observational, 12-month cohort study to understand treatment patterns and to evaluate the clinical...
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Subcutaneous abatacept for the treatment of rheumatoid arthritis in routine clinical practice in Germany, Austria, and Switzerland: 2-year retention and efficacy by treatment line and serostatus
Introduction/objectivesThe ASCORE study on treatment for rheumatoid arthritis (RA) showed better retention and clinical response rates for abatacept...
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Managing established bronchopulmonary dysplasia without using routine blood gas measurements
ObjectiveRoutine blood gas measurements are common in infants with severe bronchopulmonary dysplasia (sBPD) and are a noxious stimulus. We developed...
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The routine clinical use of fluorodeoxyglucose PET/CT to confirm treatment response in pyogenic spine infection
ObjectiveResponse of pyogenic spine infection to antibiotic therapy is usually based on nonspecific symptoms and inflammation markers. Abnormalities...
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Is Routine Post-operative Biological Laboratory Assessment Necessary After Sleeve Gastrectomy?
BackgroundIncidence of post-operative complications after sleeve gastrectomy (SG) is low. However, the early identification of these complications...
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Does the addition of whole-body MRI to routine imaging influence real-world treatment decisions in metastatic breast cancer?
BackgroundThe assessment of metastatic breast cancer (MBC) can be limited with routine imaging such as computed tomography (CT) especially in...
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Routine Upper Gastrointestinal Series Post-bariatric Surgery: Predictors, Usage, and Utility
ObjectiveTo investigate usage and utility of routine upper gastrointestinal (UGI) series in the immediate post-operative period to evaluate for leak...
