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Assessment of the uniform field electroretinogram for mouse retinal ganglion cell functional analysis
PurposeThe uniform field electroretinogram (UF-ERG) has been suggested as an alternative to the pattern electroretinogram (PERG) for non-invasive...
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Retinal pathological features and proteome signatures of Alzheimer’s disease
Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical...
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Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring...
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Current and novel multi-imaging modalities to assess retinal oxygenation and blood flow
Retinal ischemia characterizes the underlying pathology in a multitude of retinal diseases that can ultimately lead to vision loss. A variety of...
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Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series
BackgroundNon-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute optic neuropathy in patients over 50 years of...
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Retinal blood flow in critical illness and systemic disease: a review
BackgroundAssessment and maintenance of end-organ perfusion are key to resuscitation in critical illness, although there are limited direct methods...
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The retinal function imager and clinical applications
BackgroundThe Retinal Function Imager (RFI) provides in vivo and noninvasive imaging of both the retinal structure and function.
Review ...
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Diminazene aceturate or losartan ameliorates the functional, radiological and histopathological alterations in knee osteoarthritis rodent model: repurposing of the ACE2/Ang1-7/MasR cascade
PurposeCurrent therapies for osteoarthritis (OA) are limited to analgesics and anti-inflammatory drugs. Considering the importance of oxidative...
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Retinal oximetry and fractal analysis of capillary maps in sickle cell disease patients and matched healthy volunteers
PurposeFractal analysis can be used to quantitatively analyze the retinal microvasculature and might be a suitable method to quantify retinal...
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Histological and molecular characterization of glaucoma model induced by one or two injections of microbeads to the anterior chamber of mice
PurposeTo characterize glaucoma-induced damage following injections of plastic microbeads into the anterior chamber of mice.
MethodsMice were...
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Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography
PurposeTo study the retinal capillary microvasculature and the choriocapillaris (CC) in myopic eyes using swept-source optical coherence tomography...
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Identification of a novel RPGR mutation associated with X-linked cone-rod dystrophy in a Chinese family
BackgroundCone-rod dystrophy (CORD) is a group of inherited retinal dystrophies, characterized by decreased visual acuity, color vision defects,...
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The effect of sildenafil on retinal blood velocity in healthy subjects
PurposeIt has been suggested that Sildenafil may have beneficial therapeutic effects in the treatment of neurodegenerative disorders. The retinal...
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SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration
GEMIN5 is essential for core assembly of small nuclear Ribonucleoproteins (snRNPs), the building blocks of spliceosome formation. Loss-of-function...
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Retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes
BackgroundThe aim was to determine retinal nerve fiber layer function and its relations to retinal microvasculature and microcirculation in patients...
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Optical coherence tomography angiography analysis of changes in the foveal avascular zone in eyes with diabetic macular edema treated with intravitreal anti-vascular endothelial growth factor
BackgroundTo analyze the changes in foveal avascular zone (FAZ) area, perimeter, and circularity in the superficial (SCP) and deep (DCP) capillary...
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Depleting hypothalamic somatostatinergic neurons recapitulates diabetic phenotypes in mouse brain, bone marrow, adipose and retina
Aims/hypothesisHypothalamic inflammation and sympathetic nervous system hyperactivity are hallmark features of the metabolic syndrome and type 2...
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miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8
BackgroundDiabetic nephropathy (DN) is one of the most common and serious complications of diabetes, which can lead to renal failure and fatality....
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Retinal tissue hypoperfusion in patients with clinical Alzheimer’s disease
BackgroundIt remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer’s disease. The goal was to determine retinal tissue...
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Microcirculation in the conjunctiva and retina in healthy subjects
BackgroundThe aim was to determine the relationship between bulbar conjunctival microcirculation and retinal microcirculation in a healthy population.
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