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Enhanced renal clearance impacts levetiracetam concentrations in patients with traumatic brain injury with and without augmented renal clearance
BackgroundThe purpose of this study was to examine the impact of ARC on levetiracetam concentrations during the first week following acute TBI. The...
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Predictors of augmented renal clearance based on iohexol plasma clearance in critically ill children
BackgroundAugmented renal clearance (ARC) holds a risk of subtherapeutic drug concentrations. Knowledge of patient-, disease-, and therapy-related...
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What is New in Augmented Renal Clearance in Septic Patients?
Purpose of ReviewIn this narrative review encompassing relevant scientific publications regarding critically ill patients in the last 5 years, we...
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Personalized application of antimicrobial drugs in pediatric patients with augmented renal clearance: a review of literature
The effect of renal functional status on drug metabolism is a crucial consideration for clinicians when determining the appropriate dosage of...
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Clinical implications of augmented renal clearance after unrelated single cord blood transplantation in adults
Augmented renal clearance (ARC) is a phenomenon characterized by increased renal functionality, which can impact the pharmacokinetics and...
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Different distances between central venous catheter tips can affect antibiotic clearance during continuous renal replacement therapy
BackgroundThe aim of this experimental study was to elucidate whether different distances between central venous catheter tips can affect drug...
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First-in-human validation of enzymolysis clearance strategy for decreasing renal radioactivity using modified [68Ga]Ga-HER2 Affibody
PurposeEnzymolysis clearance strategy, characterized by releasing the non-reabsorbable radioactive fragment under the specific cleavage of enzymes,...
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Evaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach
Background and ObjectiveChronic kidney disease (CKD) may alter drug renal elimination but is also known for interacting with hepatic metabolism via...
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In an endotoxaemic model, antibiotic clearance can be affected by different central venous catheter positions, during renal replacement therapy
BackgroundIn intensive care, different central venous catheters (CVC) are often used for infusion of drugs. If a patient is treated with continuous...
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Risk factors associated with augmented renal clearance in a mixed intensive care unit population: a retrospective study
BackgroundAugmented renal clearance is increasingly recognized in critically ill patients. This condition may lead to suboptimal dosing of renally...
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Onset timing and duration of augmented renal clearance in a mixed intensive care unit
BackgroundAugmented renal clearance (ARC) is associated with lower blood plasma concentrations of renally excreted drugs; however, its time course is...
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Augmented Renal Clearance in Patients with Acute Ischemic Stroke: A Prospective Observational Study
BackgroundAugmented renal clearance (ARC) is a phenomenon that has been demonstrated in many subsets of critically ill patients and is characterized...
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Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences—a retrospective observational study
BackgroundAugmented renal clearance (ARC) remains poorly evaluated in ICU. The objective of this study is to provide a full description of ARC in ICU...
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Age-associated augmented renal clearance and low BMI trigger suboptimal vancomycin trough concentrations in children with haematologic diseases: data of 1453 paediatric patients from 2017 to 2022
BackgroundIt is usually difficult for the trough concentration of vancomycin to reach the recommended lower limit of 10 mg/L per the label dose in...
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Significant Effects of Renal Function on Mycophenolic Acid Total Clearance in Pediatric Kidney Transplant Recipients with Population Pharmacokinetic Modeling
Background and ObjectivesMycophenolic acid (MPA) is an immunosuppressant commonly prescribed in pediatric kidney transplantation to prevent graft...
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Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents
Background and ObjectivesMilrinone is an inotrope and vasodilator used for prophylaxis or treatment of low cardiac output syndrome after weaning from...
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Age-Related Change in Hepatic Clearance Inferred from Multiple Population Pharmacokinetic Studies: Comparison with Renal Clearance and Their Associations with Organ Weight and Blood Flow
ObjectiveThis study aimed to examine the magnitude of age-related change in hepatic clearance by integrating the data of multiple drugs and to...
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Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report
BackgroundHepatic insulin clearance (HIC) is an important pathophysiology of type 2 diabetes mellitus (T2DM). HIC was reported to decrease in...
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Comparison of inulin clearance with 2-h creatinine clearance in Japanese pediatric patients with renal disease: open-label phase 3 study of inulin
BackgroundThere is no approved dosage and administration of inulin for children. Therefore, we measured inulin clearance (Cin) in pediatric patients...
