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Efficacy of dupilumab in real-life settings: a STROBE study
BackgroundDupilumab, a monoclonal antibody targeting IL-4 and IL-13, has demonstrated its efficacy in several clinical trials. However, to date,...
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Belimumab corticosteroid-sparing treatment in systemic lupus erythematosus: a real-life observational study (BESST study)
Data about the impact of Belimumab on corticosteroid sparing in real life are scarce. To assess the corticosteroid-sparing effect among patients with...
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Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics
PurposeAsthma negatively impacts health-related quality of life (HRQL). The objective is to investigate the longitudinal relationship between HRQL in...
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Impact of a digital web-based asthma platform, a real-life study
BackgroundDigital health technology (DHT) is a growing area in the treatment of chronic diseases. Study results on DHT’s effect on asthma control...
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Long-term real-life outcomes of the Clareon® hydrophobic intraocular lens: the Clarte study in 191 eyes
BackgroundTo describe and analyze the real-life refractive, functional and safety outcomes of the Clareon® intraocular lens (IOL) after 3 years.
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Disease Stage and Motor Fluctuation Duration Predict Drug Tolerability: A Real-Life, Prospective Italian Multicenter Study on the Use of Opicapone in Parkinson’s Disease
BackgroundOpicapone is a third-generation catechol- O -methyl-transferase inhibitor currently used for the treatment of motor fluctuations in...
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Omalizumab Treatment in Uncontrolled Asthma and CRSwNP Patients, with Previous Endoscopic Sinus Surgery, to Improve Quality of Life and Endoscopic Outcomes: a Two-Year Real-Life Study
Purpose of ReviewDespite molecular underlying advances, limited and divergent data on monoclonal antibodies (mAb) therapy in chronic rhinosinusitis...
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The Evaluation of Effectiveness and Safety of Guselkumab in Patients with Psoriatic Arthritis in a Prospective Multicentre “Real-Life” Cohort Study
IntroductionGuselkumab is an interleukin-23 (IL-23) inhibitor licensed for the treatment of psoriatic arthritis (PsA). This study aimed to evaluate...
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Temporal trends of blood eosinophilia in severe uncontrolled CRSwNP treated with dupilumab: a real-life study
PurposeInduced eosinophilia is commonly related to dupilumab treatment. We analysed the temporal trends of blood eosinophilia in patients with severe...
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Real-Life Experience of Tralokinumab for the Treatment of Adult Patients with Severe Atopic Dermatitis: A Multicentric Prospective Study
BackgroundTralokinumab, the first fully human monoclonal antibody that binds specifically to interleukin-13, was safe and effective for treating...
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Real-life instability in ADHD from young to middle adulthood: a nationwide register-based study of social and occupational problems
BackgroundStudies using self-reports indicate that individuals with ADHD are at increased risk for functional impairments in social and occupational...
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Linear growth of children with X-linked hypophosphatemia treated with burosumab: a real-life observational study
To assess the long-term efficacy of burosumab for pediatric patients with X-linked hypophosphatemia, focusing on linear growth. This multi-center...
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Comparison between available early antiviral treatments in outpatients with SARS-CoV-2 infection: a real-life study
PurposeTo investigate the clinical impact of three available antivirals for early COVID-19 treatment in a large real-life cohort.
Methods ...
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Quality of Life Evaluation in Patients with Follicular Cell Lymphoma: A Real-World Study in Europe and the United States
IntroductionFollicular lymphoma (FL) is an indolent subtype of non-Hodgkin's lymphoma (NHL), characterized by a long natural course of...
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Secukinumab in Patients with Psoriasis and a Personal History of Malignancy: A Multicenter Real-Life Observational Study
IntroductionThere is limited evidence to guide clinicians on the treatment of psoriasis with biologics in patients with a history of malignancy who...
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Observational real-life study on regorafenib in recurrent glioblastoma: does dose reduction reduce toxicity while maintaining the efficacy?
PurposeIn the phase 2 REGOMA trial, regorafenib improved overall survival, as compared with lomustine, in glioblastoma (GBM) patients at first...
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Real-life experiences with galcanezumab and predictors for treatment response in Turkey
BackgroundThe complexity of clinical practice extends far beyond the controlled settings of trials, and there is a need for real-world studies aimed...
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A 12-month prospective real-life study of opicapone efficacy and tolerability in Emirati and non-White subjects with Parkinson’s disease based in United Arab Emirates
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and the condition is complicated by the emergence of wearing off/motor...
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Dupilumab Treatment in Children Aged 6–11 Years With Atopic Dermatitis: A Multicentre, Real-Life Study
BackgroundThe management of paediatric atopic dermatitis (AD) is challenging, mostly relying on emollients and topical corticosteroids. Dupilumab, a...
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A real-life study of daratumumab-bortezomib-dexamethasone (D-VD) in lenalidomide exposed/refractory multiple myeloma patients: a report from the Triveneto Myeloma Working Group
Treatment of lenalidomide refractory (Len-R) multiple myeloma (MM) patients still represents an unmet clinical need. In the last years,...
