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Stapler-lavage cytology using a new rapid immunocytochemistry for evaluating surgical margin status after pulmonary sublobar resection
ObjectiveSublobar resection is considered the gold standard for selected patients with pulmonary metastasis or who are compromised in some way....
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Immunocytochemistry on frozen-embedded cell block for the diagnosis of hematolymphoid cytology specimen: a straightforward alternative to the conventional cell block
Agarose-based cell block (CB) technique can be modified to be combined with the frozen section technique for the preparation of a high-quality...
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Intraoperative rapid diagnosis of pleural lavage cytology in non-small cell lung cancer
ObjectivePositive pleural lavage cytology (PLC +) is a poor prognostic factor for non-small cell lung cancer (NSCLC). However, data on the impact of...
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Surgical intervention for non-small-cell lung cancer with minimal malignant pleural effusion
PurposeWe assessed the clinical significance of minimal malignant pleural effusion (MPE) using liquid-based cytology (LBC) and immunocytochemistry...
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Role of FMRP in rapid antidepressant effects and synapse regulation
Rapid antidepressants are novel treatments for major depressive disorder (MDD) and work by blocking N-methyl-D-aspartate receptors (NMDARs), which,...
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The diagnostic utility of cytology specimen in a case of EWSR1::NFATC2 sarcoma
EWSR1::NFATC2 sarcoma, a rare round cell sarcoma constituting the majority of EWSR1 ::non-ETS sarcomas, has recently been defined in the latest WHO...
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Stroma-derived neoplasms and pseudoneoplastic lesions of the spleen: a select review of pathologic and CT/MRI findings
A wide spectrum of benign and malignant primary mesenchymal tumors and tumor-like lesions of the spleen has been recently included under the umbrella...
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A novel ADC targeting cell surface fibromodulin in a mouse model of triple-negative breast cancer
BackgroundTriple-negative breast cancers (TNBCs) are highly aggressive and metastatic. To date, finding efficacious targeted therapy molecules might...
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Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules
BackgroundMotor neuron degeneration or loss in the spinal cord is the characteristic phenotype of motor neuron diseases or spinal cord injuries....
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Rapid Effects of Oestrogen on Intracellular Ca2+ in the Uterine Junctional Myometrium of Patients With and Without Adenomyosis in Different Phases of the Menstrual Cycle
We investigated the role of oestrogen receptor 1 (ESR1) in regulating the [Ca 2+ ]i concentration in the junctional zone (JZ) and its effect on...
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SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer’s disease
Dysfunctional RNA-binding proteins (RBPs) have been implicated in several neurodegenerative disorders. Recently, this paradigm of RBPs has been...
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Circulating cancer giant cells with unique characteristics frequently found in patients with myelodysplastic syndromes (MDS)
Myelodysplastic syndromes (MDS) are incurable diseases characterized by dysplastic hematopoietic cells, cytopenias in the blood and an inherent...
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Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression
Ketamine is clinically used fast-acting antidepressant. Its metabolite hydroxynorketamine (HNK) shows a robust antidepressant effect in animal...
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Acute lymphoblastic leukemia simulating breast carcinoma
BackgroundBreast metastasis in hematological malignancies is a rare phenomenon, and it is primarily seen in acute myeloid leukemia (AML). In patients...
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Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients
BackgroundExtra pulmonary manifestation of tuberculosis (TB) accounts for approximately one-half of TB cases in HIV-infected individuals with pleural...
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Autoimmune processes in neurological patients are much more common than presently suspected
Autoimmune encephalitides are seldom diseases. How rare they actually are, however, is not known. The low incidence combined with the problematic...
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Development of New CD38 Targeted Peptides for Cancer Imaging
PurposeMultiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emission Tomography (PET)...
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The therapeutic potential of adipose tissue-derived mesenchymal stromal cells in the treatment of busulfan-induced azoospermic mice
PurposeThe generation of germ cells from mesenchymal stromal cells (MSCs) provides a valuable in vitro platform for infertility modeling. The...
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The role of SK3 in progesterone-induced inhibition of human fallopian tubal contraction
BackgroundNormal motor activity of the fallopian tube is critical for human reproduction, and abnormal tubal activity may lead to ectopic pregnancy...
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This ‘Rose’ Has no Thorns—Diagnostic Utility of ‘Rapid On-Site Evaluation’ (ROSE) in Fine Needle Aspiration Cytology
Fine needle aspiration (FNA) cytology is a basic diagnostic technique used to investigate superficial and deep swellings. Rapid on-site evaluation...
