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Unravelling the possibilities: a cross-over randomised controlled feasibility trial on immersive virtual reality in haemodialysis
BackgroundResearch pertaining to the use of Virtual Reality (VR) in various healthcare settings is emerging. The aim of this study was to assess the...
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Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers
BackgroundWe investigated whether plasma volume (PV) expansion of 20% albumin is larger when the fluid is administered rapidly compared with a slow...
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Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol
BackgroundPatients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral...
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3D printing vs traditional workflow for the fabrication of mandibular implant overdentures: study protocol for a mixed-methods cross-over RCT
BackgroundComplete tooth loss is a significant global oral health issue, particularly impacting older individuals with lower socioeconomic status....
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Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial
BackgroundBetaine is an “alternate” methyl donor for homocysteine remethylation catalyzed by betaine homocysteine methyltransferase (BHMT), an enzyme...
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Acute effects of game-based biofeedback training on trunk motion in chronic low back pain: a randomized cross-over pilot trial
BackgroundImproving movement control might be a promising treatment goal during chronic non-specific low back pain (CLBP) rehabilitation. The...
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Understanding mechanisms of depression prevention: study protocol of a randomized cross-over trial to investigate mechanisms of mindfulness and positive fantasizing as intervention techniques for reducing perseverative cognition in remitted depressed individuals
BackgroundMajor Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders, and involves high relapse rates in which persistent...
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Statistical recommendations for count, binary, and ordinal data in rare disease cross-over trials
BackgroundRecommendations for statistical methods in rare disease trials are scarce, especially for cross-over designs. As a result various...
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The impact of a blend of Pistacia atlantica seed and canola oil compared with a blend of corn-canola oil with synthetic antioxidant and corn-canola oil without synthetic antioxidant on oxidative stress markers in patients with metabolic syndrome: protocol for a triple-blind, randomized, three-way cross-over clinical trial
BackgroundMetabolic syndrome (MetS) is regarded as a complex metabolic disorder. Recently, the role of dietary antioxidants in the underlying...
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Immediate and six-week effects of wearing a knee sleeve following anterior cruciate ligament reconstruction on knee kinematics and kinetics: a cross-over laboratory and randomised clinical trial
BackgroundElastic knee sleeves are often worn following anterior cruciate ligament reconstruction (ACLR) but their effects on movement patterns are...
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The Effects of the Presence of Others on Risky Betting in a Laboratory Gambling Task Among High-Risk Gamblers: A Cross-over Randomized Controlled Trial
We explored the effects of the presence of and cooperation with others on risky betting in a laboratory-based gambling task among high-risk gamblers....
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The effect of ascending- descending ultrafiltration and sodium profiles on blood pressure in hemodialysis patients: a randomized cross-over study
BackgroundConsidering no previous research into the utilization of ascending/descending ultrafiltration and linear sodium profiles in improving blood...
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The ELSA trial: single versus combinatory effects of non-prohibited beta-2 agonists on skeletal muscle metabolism, cardio-pulmonary function and endurance performance—study protocol for a randomized 4-way balanced cross-over trial
BackgroundAsthma and/or airway hyper-responsiveness (AHR) are common in elite endurance athletes with a high prevalence rate of beta-2 adrenoreceptor...
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Determining the effects of targeted high-definition transcranial direct current stimulation on reducing post-stroke upper limb motor impairments—a randomized cross-over study
BackgroundStroke is one of the leading causes of death in the USA and is a major cause of serious disability for adults. This randomized crossover...
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Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios
As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of...
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Immediate and 6-week effects of wearing a knee sleeve following anterior cruciate ligament reconstruction: a cross-over laboratory and randomised clinical trial
BackgroundRehabilitation following anterior cruciate ligament (ACL) reconstructions is based mainly on comprehensive progressive exercise programmes...
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A randomized double-blind cross-over trial to study the effects of resistant starch prebiotic in chronic kidney disease (ReSPECKD)
BackgroundChronic kidney disease (CKD) is associated with a reduced quality of life and an increased risk of kidney failure, cardiovascular events,...
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Should I Rest or Should I Go Now? A Randomized Cross-Over Trial Comparing Fixed and Self-Selected Rest Durations in High-Intensity Interval Training Cycling Sessions
BackgroundIn high-intensity interval training (HIIT), the rest durations between intervals are commonly prescribed using a fixed approach (e.g., 30 s...
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The influence of coffee consumption on bioelectrical impedance parameters: a randomized, double-blind, cross-over trial
BackgroundBioelectrical impedance analysis (BIA) is a widely used method for estimating body composition. Avoiding foods/beverages containing...
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Discomfort improvement for critically ill patients using electronic relaxation devices: results of the cross-over randomized controlled trial E-CHOISIR (Electronic-CHOIce of a System for Intensive care Relaxation)
PurposeTo assess the impact of different electronic relaxation devices on common stressful patient symptoms experienced in intensive care unit (ICU).
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