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Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): A Qualitative Study Exploring the Trial Team’s Facilitators and Challenges in Conducting a Feasibility Trial in India
BackgroundIn India, around 77 million people are at high risk of develo** type 2 diabetes mellitus (T2DM). Yoga interventions can be effective in...
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The POP (Permanent Supportive Housing Overdose Prevention) Study: protocol for a hybrid type 3 stepped-wedge cluster randomized controlled trial
BackgroundPermanent supportive housing (PSH)—subsidized housing paired with support services such as case management—is a key part of national...
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Study protocol: group-based psychoeducation for relatives of patients with bipolar disorder—a large scale real-world randomized controlled parallel group trial, the R-bipolar RCT
BackgroundRelatives of patients with bipolar disorder (BD) often experience emotional burden with stress and depressive symptoms that again increase...
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The effectiveness of pharmacist-led educational model in adult patients with allergic rhinitis: a single-center randomized control trial protocol (AR-PRISE RCT)
BackgroundAllergic rhinitis is a chronic respiratory disorder that significantly impacts patients’ quality of life (QoL) and work performance....
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Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial
IntroductionMany Indians are at high risk of type 2 diabetes mellitus (T2DM). The blood glucose level can be improved through a healthy lifestyle...
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Effectiveness of artificial intelligence vs. human coaching in diabetes prevention: a study protocol for a randomized controlled trial
BackgroundPrediabetes is a highly prevalent condition that heralds an increased risk of progression to type 2 diabetes, along with associated...
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The effect of combining therapeutic drug monitoring of antihypertensive drugs with personalised feedback on adherence and resistant hypertension: the (RHYME-RCT) trial protocol of a multi-centre randomised controlled trial
BackgroundAdherence to antihypertensive drugs (AHDs) is important for adequate blood pressure control. Not taking these drugs as prescribed is one of...
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Subthreshold opioid use disorder prevention (STOP) trial: a cluster randomized clinical trial: study design and methods
BackgroundPreventing progression to moderate or severe opioid use disorder (OUD) among people who exhibit risky opioid use behavior that does not...
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Managed care updates of subscriber jail release to prompt community suicide prevention: clinical trial protocol
BackgroundRecent jail detention is a marker for trait and state suicide risk in community-based populations. However, healthcare providers are...
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Tailored implementation of national recommendations on fall prevention among older adults in municipalities in Norway (FALLPREVENT trial): a study protocol for a cluster-randomised trial
BackgroundDespite substantial research evidence indicating the effectiveness of a range of interventions to prevent falls, uptake into routine...
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High School Follow-Up of the Dating Matters® RCT: Effects on Teen Dating Violence and Relationship Behaviors
Teen dating violence (TDV) is a significant public health problem that can have lifelong consequences. Using a longitudinal, cluster randomized...
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Conducting a diabetes mellitus prevention trial in women with GDM in Pakistan: a feasibility study
BackgroundWomen with gestational diabetes mellitus (GDM) are at a greater risk of develo** type 2 diabetes mellitus (T2DM) than women without GDM....
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Stereotactic Body radiotherapy and pedicLE screw fixatioN During one hospital visit for patients with symptomatic unstable spinal metastases: a randomized trial (BLEND RCT) using the Trials within Cohorts (TwiCs) design
BackgroundSpinal metastases can lead to unremitting pain and neurological deficits, which substantially impair daily functioning and quality of life....
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A pilot feasibility and acceptability trial of an internet indicated prevention program for perfectionism to reduce eating disorder symptoms in adolescents
PurposePerfectionism is a transdiagnostic risk factor for eating disorders. Treating perfectionism can reduce symptoms of eating disorders. No...
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Results from the BETTER WISE trial: a pragmatic cluster two arm parallel randomized controlled trial for primary prevention and screening in primary care during the COVID-19 pandemic
BackgroundCancer and chronic diseases are a major cost to the healthcare system and multidisciplinary models with access to prevention and screening...
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A Randomized Controlled Trial of Acid and Bile Reflux Esophagitis Prevention by Modified Fundoplication of the Excluded Stomach in One-Anastomosis Gastric Bypass: 1-Year Results of the FundoRing Trial
BackgroundThe advantages and disadvantages of one-anastomosis gastric bypass (OAGB) with primary modified fundoplication using the excluded stomach...
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Using Mobile Technology for Family-Based Prevention in Families with Low Incomes: Lessons from a Randomized Controlled Trial of a Childhood Obesity Prevention Program
Researchers are increasingly using web-based technologies to deliver family-based, prevention programming. Few studies have examined the success of...
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Motivational interviewing to promote healthy behaviors for obesity prevention in young adults (MOTIVATE): a pilot randomized controlled trial protocol
BackgroundObesity is a chronic disease and is an established risk factor for other chronic diseases and mortality. Young adulthood is a period when...
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Comparison of different statistical models for the analysis of fracture events: findings from the Prevention of Falls Injury Trial (PreFIT)
BackgroundFractures are rare events and can occur because of a fall. Fracture counts are distinct from other count data in that these data are...
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Subgroup Analyses of Girl2Girl, a Text Messaging-Based Teen Pregnancy Prevention Program for Sexual Minority Girls: Results from a National RCT
This study aims to investigate whether Girl2Girl, a text messaging-based pregnancy prevention program for cisgender LGB+ girls, had different effects...
