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Protocolized Sedation Utilizing COMFORT-B Scale versus Non-protocol-directed Sedation in Mechanically Ventilated Children — An Open-label, Randomized Controlled Trial
This study aimed to determine the effect of protocolized sedation using the COMFORT-B scale on the duration of mechanical ventilation (DMV). Eighty...
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Optimizing patient outcomes: a comprehensive evaluation of protocolized sedation in intensive care settings: a systematic review and meta-analysis
IntroductionAmidst the routine utilization of protocolized sedation in ventilated ICU patients, existing management guidelines exhibit a lack of...
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Postoperative recovery among head and neck cancer patients receiving microvascular free flap surgery with implementing nurse-protocolized targeted sedation: relationship of use of sedatives and mechanical ventilation to length of ICU stay
PurposePatients receiving microvascular free flap surgery are usually admitted to a high-dependency adult intensive care unit (ICU). Research is...
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Sedation in pediatric intensive care unit and its impact on outcomes of ventilated children: a prospective observational study
BackgroundSedation is an integral part in the management of critical patients in the pediatric intensive care unit (PICU). Optimum sedation is when...
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Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial
BackgroundThe objective of this study was to analyze the impact of a structured educational intervention on the implementation of...
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Trans rectus sheath extra-peritoneal procedure (TREPP) for inguinal hernia repair under local anesthesia with sedation in the outpatient clinic: a feasibility study
BackgroundThe Trans Rectus Sheath Extra-Peritoneal Procedure (TREPP) is an open procedure in which the mesh is placed in the preperitoneal space and...
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Analgesia and sedation in critically ill pediatric patients: an update from the recent guidelines and point of view
In the last decades, the advancement of knowledge in analgesia and sedation for critically ill pediatric patients has been conspicuous and relevant....
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Pain and sedation management and monitoring in pediatric intensive care units across Europe: an ESPNIC survey
BackgroundManagement and monitoring of pain and sedation to reduce discomfort as well as side effects, such as over- and under-sedation, withdrawal...
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Recommendations for analgesia and sedation in critically ill children admitted to intensive care unit
We aim to develop evidence-based recommendations for intensivists caring for children admitted to intensive care units and requiring analgesia and...
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Challenges in Sedation Management in Critically Ill Patients with COVID-19: a Brief Review
Purpose of ReviewTo highlight the challenges associated with providing sedation and analgesia to critically ill patients with coronavirus disease...
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A multicomponent intervention program to Prevent and Reduce AgItation and phySical rEstraint use in the ICU (PRAISE): study protocol for a multicenter, stepped-wedge, cluster randomized controlled trial
BackgroundPhysical restraints remain to be commonly used in agitated intensive care unit (ICU) patients worldwide, despite a lack of evidence on...
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Analgesia and sedation in patients with ARDS
Acute Respiratory Distress Syndrome (ARDS) is one of the most demanding conditions in an Intensive Care Unit (ICU). Management of analgesia and...
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Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial
ObjectiveTo demonstrate feasibility of a music medicine intervention trial in pediatric intensive care and to obtain information on sedation and...
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Adjunctive ketamine for sedation in critically ill mechanically ventilated patients: an active-controlled, pilot, feasibility clinical trial
ObjectiveKetamine has been shown to decrease sedative requirements in intensive care unit (ICU). Randomized trials are limited on patient-centered...
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Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
PurposeTo compare the effects of prevention interventions on delirium occurrence in critically ill adults.
MethodsMEDLINE, Embase, PsychINFO,...
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Establishing Carotid Seldinger as Routine Access in Infants; Planning, Performance, and Follow-Up Protocols
Percutaneous carotid access (PCA) in infants has been reported in small multicenter cohorts, case reports and wider studies over the last 20 years....
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Continuous Electroencephalography Markers of Prognostication in Comatose Patients on Extracorporeal Membrane Oxygenation
BackgroundWe aimed to identify continuous electroencephalogram (cEEG) markers associated with survival and death in patients with extracorporeal...
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Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial
PurposeThe effect of renal replacement therapy (RRT) in comatose patients with acute kidney injury (AKI) remains unclear. We compared two RRT...
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Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial
PurposeTo quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with usual care, and...
