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Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma
BackgroundAdenocarcinomas show a stepwise progression from atypical adenomatous hyperplasia (AAH) through adenocarcinoma in situ (AIS) to invasive...
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Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats
Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown....
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Metabolic profile and gene expression pattern of cytokines and antioxidants markers during different physiological stages in Barki ewes
BackgroundIn livestock, identifying the physiological and reproductive stages is valuable in guiding management decisions related to nutrition,...
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Expression Profile of KRAS and p16 in Periampullary Cancer
Activating point mutations in codons 12, 13, and 61 of the KRAS gene and loss of p16 expression, a tumor suppressor gene, are common genetic...
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Characterization of the circulating transcriptome expression profile and identification of novel miRNA biomarkers in hypertrophic cardiomyopathy
BackgroundHypertrophic cardiomyopathy (HCM), one of the most common genetic cardiovascular diseases, but cannot be explained by single genetic...
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Multi-omics analysis of expression profile and prognostic values of connexin family in LUAD
PurposeOur study first explored the expression differences and prognostic significance of Cx genes in pan-cancer and then focused on LUAD. Our...
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The endoplasmic reticulum stress protein GRP94 modulates cathepsin L activity in M2 macrophages in conditions of obesity-associated inflammation and contributes to their pro-inflammatory profile
Background/objectivesAdipose tissue macrophages (ATM) are key actors in the pathophysiology of obesity-related diseases. They have a unique...
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Expression analysis and map** of Viral—Host Protein interactions of Poxviridae suggests a lead candidate molecule targeting Mpox
BackgroundMonkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding...
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Profile and clinical significance of interferon gamma-inducible protein-10 (IP-10) and its receptor in patients with hepatocellular carcinoma
BackgroundChemokines play a vital role in tumor progression, metastasis and prognosis; however, the profile and clinical significance of gamma...
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High-throughput RNA sequencing identifies the miRNA expression profile, target genes, and molecular pathways contributing to growth of sporadic vestibular schwannomas
PurposeTo assess the differences in the miRNA expression profile between small (stage I Koos classification) and large solid vestibular schwannoma...
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The influence of selected microRNAs on the expression profile of genes and proteins related to the tumor necrosis factor-alpha signaling pathways in endometrioid endometrial cancer
PurposeTumor necrosis factor exerts many adverse biological effects, from cell proliferation to cell death. Accurate diagnosis and treatment are...
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Distinct global DNA methylation and NF-κB expression profile of preimplantation biopsies from ideal and non-ideal kidneys
BackgroundEpigenetic mechanisms may affect the ideal and non-ideal kidneys selected for transplantation and their inflammatory gene expression...
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Human cytomegalovirus-encoded microRNAs expression profile in plasma of patients with aortic dissection
BackgroundAortic dissection (AD) is a rare disease with high mortality for which no effective diagnostic biomarkers are available. Human...
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High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes
BackgroundHigh fat diet (HFD) increases the likelihood of dyslipidemia, which can be a serious risk factor for atherosclerosis, diabetes or...
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High Fatty Acid-Binding Protein 4 Expression Associated with Favorable Clinical Characteristics and Prognosis in Papillary Thyroid Carcinoma
Fatty acid-binding protein 4 ( FABP4 ), a fatty acid transporter that coordinates lipid metabolism, is reported to exert a tumorigenic role in certain...
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The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity
African swine fever virus (ASFV) is a highly contagious and deadly virus that leads to high mortality rates in domestic swine populations. Although...
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Comprehensive analysis of circRNA expression profile and circRNA-miRNA-mRNA network susceptibility to very early-onset schizophrenia
To explore the potential role of circular RNAs (circRNAs) in children develo** very early-onset schizophrenia (VEOS). Total RNA was extracted from...
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Immune endoty** and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups
BackgroundChronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps...
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Expression of the microtubule-associated protein 2 (MAP2) as a potential independent prognostic marker in prostate cancer
PurposeInvestigation of Microtubuli-associated Protein 2 (MAP2) expression and its clinical relevance in prostate cancer.
Material and Methods ...
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Expression of unfolded protein response genes in post-transplantation liver biopsies
BackgroundCholestatic liver diseases are a major source of morbidity and mortality that can progress to end-stage liver disease and...
