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Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Macrophages exhibit different functional states and are classified...
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Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH), is a type of pulmonary vascular disease characterized by...
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In vitro effect of relaxin in the rat corpus cavernosum under hyperglycemic and normoglycemic conditions
Relaxin, an endogenous peptide hormone, elicits vascular relaxation by its direct effect or by modulating the endothelium-dependent relaxation...
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Atraumatisches Knochenmarködem des Kniegelenks
Bone marrow edema (BME) represents a magnetic resonance imaging (MRI) phenomenon characterized by hypointensity on T1-weighted images and...
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Novel Drugs for the Treatment of Pulmonary Arterial Hypertension: Where Are We Going?
Pulmonary arterial hypertension (PAH) is a progressive disease that despite advances in therapy is associated with a 7-year survival of approximately...
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Acute effects of inhaled iloprost on intracardiac conduction in patients with pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension (PAH) is a severe, life-threatening disorder despite the availability of specific drug therapy. A lack of...
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Divergent roles of prostacyclin and PGE2 in human tendinopathy
BackgroundTendon disease is a significant global healthcare burden whereby patients experience pain and disability; however, the mechanisms that...
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Molecular docking prediction and in vitro studies elucidate anti-inflammatory effect of Garcinia extract against inducible nitric oxide synthase and cyclooxygenase-2 targets
BackgroundGarcinia is a tropical plant that has been traditionally used in medicinal folklore for its potential antioxidant, antibacterial,...
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The Antifibrotic Effects of Inhaled Treprostinil: An Emerging Option for ILD
Interstitial lung diseases (ILD) encompasses a heterogeneous group of parenchymal lung diseases characterized by variable amounts of inflammation and...
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Imbalanced prostanoid release mediates cigarette smoke-induced human pulmonary artery cell proliferation
BackgroundPulmonary hypertension is a common and serious complication of chronic obstructive pulmonary disease (COPD). Studies suggest that cigarette...
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Systematic Review Article: New Drug Strategies for Treating Resistant Hypertension—the Importance of a Mechanistic, Personalized Approach
Resistant hypertension (RHT) is characterized by persistently high blood pressure (BP) levels above the widely recommended therapeutic targets of...
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Pulmonary Complications of the Liver
Purpose of ReviewHepatic hydrothorax (HH), hepatopulmonary syndrome (HPS), and portopulmonary hypertension (PoPH) are the most common complications...
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Future Perspectives of Pulmonary Arterial Hypertension: A Review of Novel Pipeline Treatments and Indications
Pulmonary arterial hypertension is characterized by elevated blood pressure and pathological changes in the pulmonary arterioles, leading to the...
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The Importance of Integrated Regulation Mechanism of Coronary Microvascular Function for Maintaining the Stability of Coronary Microcirculation: An Easily Overlooked Perspective
Coronary microvascular dysfunction (CMD) refers to a group of disorders affecting the structure and function of coronary microcirculation and is...
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New progress in diagnosis and treatment of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a progressive disease. Although great progress has been made in its diagnosis and treatment in recent years,...
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Genetics of ischemic stroke functional outcome
Ischemic stroke, which accounts for 87% of cerebrovascular accidents, is responsible for massive global burden both in terms of economic cost and...
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Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway
BackgroundAtherosclerosis (AS) is the primary cause of cardiovascular disease and the incidence is extremely common; however, there are currently few...
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Deficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice
BackgroundNeutral cholesterol ester hydrolase 1 (NCEH1) plays a critical role in the regulation of cholesterol ester metabolism. Deficiency of NCHE1...
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Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches
Hesperetin is one of the prominent flavonoids found in citrus fruit. Several research studies have reported that hesperetin can promote vasodilation...
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Vascular Metabolic Mechanisms of Pulmonary Hypertension
Pulmonary hypertension (PH) is a severe and progressive disease characterized by increased pulmonary vascular resistance leading to right heart...