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Severe CSF immune cell alterations in cryptococcal meningitis gradually resolve during antifungal therapy
Cryptococcal meningitis (CM) is a severe fungal disease in immunocompromised patients affecting the central nervous system (CNS). Host response and...
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Diagnostic yield of fluorescence-assisted frame-based stereotactic biopsies of intracerebral lesions in comparison with frozen-section analysis
PurposeStereotactic biopsies are routinely used to establish a histological diagnosis of unclear cerebral pathologies. Intraoperatively,...
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Generate-Boost: study protocol for a prospective, multicenter, randomized controlled, double-blinded phase II trial to evaluate efficacy and safety of bortezomib in patients with severe autoimmune encephalitis
BackgroundAutoimmune encephalitis is a new spectrum of autoimmune disorders of the central nervous system (CNS), which are characterized by...
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Disease reactivation after switching from natalizumab to daclizumab
Discontinuation of natalizumab can lead to severe rebound of disease activity in patients with relapsing–remitting multiple sclerosis (RRMS);...
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The risk of infections in hematologic patients treated with rituximab is not influenced by cumulative rituximab dosage - a single center experience
BackgroundRituximab, a monoclonal antibody directed against CD20, is approved for the treatment of CD20-positive B-cell Non-Hodgkin’s lymphoma and...
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Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066)
IntroductionThere was a growing need for practical guidelines for the most common OIs in Germany and Austria under consideration of the local...
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Severe leukoencephalopathy with fulminant cerebral edema reflecting immune reconstitution inflammatory syndrome during HIV infection: a case report
IntroductionImmune reconstitution inflammatory syndrome is a well-known complication in HIV-infected patients after initiation of highly active...
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Immune reconstitution after haploidentical hematopoietic cell transplantation: impact of reduced intensity conditioning and CD3/CD19 depleted grafts
Haploidentical hematopoietic cell transplantation (HHCT) using CD34 selected grafts is complicated by slow engraftment and immune reconstitution....
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Encephalopathy, visual disturbance and hearing loss—recognizing the symptoms of Susac syndrome
Background . A 23 year-old female presented to a neurology department with a 3 year history of recurrent episodes involving hearing loss,...
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Effective Treatment of Patients in a Deep Salvage Situation with "Non-Active HAART": Experiences with the Expert Advice System RADATA
Background:Clinical studies suggest expert recommendations as a possibility to optimize highly active antiretroviral therapy (HAART) in patients with...
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Disease-Modifying Agents for Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease of the CNS. Currently, six medications are approved for immunmodulatory and immunosuppressive...
