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Screening for atypical porcine pestivirus in Swedish boar semen used for artificial insemination and a characterisation of the seminal RNA microbiome including the virome
BackgroundThis study aimed to characterise the RNA microbiome, including the virome of extended semen from Swedish breeding boars, with particular...
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Xenotransplantation: The Contribution of CRISPR/Cas9 Gene Editing Technology
Purpose of ReviewThis review will highlight how gene editing technology using clustered regularly interspaced short palindromic repeats (CRISPR) and...
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Cardiac Xenotransplantation: a New Frontier for Advanced Heart Failure
Purpose of reviewCardiac transplantation is a critical treatment for patients with advanced heart failure, offering the ability to markedly improve...
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Bacterial and Viral Diversity of Didelphid Opossums from Brazil
Marsupials belonging to the Didelphis genus are widely distributed in the American Continent, and Didelphis albiventris and Didelphis aurita , are...
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Progress in xenotransplantation: overcoming immune barriers
A major limitation of organ allotransplantation is the insufficient supply of donor organs. Consequently, thousands of patients die every year while...
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Diabetes current and future translatable therapies
Diabetes is one of the major diseases and concerns of public health systems that affects over 200 million patients worldwide. It is estimated that...
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Activation of immune signals during organ transplantation
The activation of host’s innate and adaptive immune systems can lead to acute and chronic graft rejection, which seriously impacts graft survival....
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Non-viral and viral delivery systems for hemophilia A therapy: recent development and prospects
Recent advancements have focused on enhancing factor VIII half-life and refining its delivery methods, despite the well-established knowledge that...
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Cardiac xenotransplantation: a promising way to treat advanced heart failure
Cardiac xenotransplantation (CXTx) might be a promising approach to bridge the gap between the supply and demand of a donor heart. The survival of...
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Heart transplantation: advances in expanding the donor pool and xenotransplantation
Approximately 65 million adults globally have heart failure, and the prevalence is expected to increase substantially with ageing populations....
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ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer
ObjectiveCisplatin (CDDP)-based chemotherapy is a first-line, drug regimen for muscle-invasive bladder cancer (BC) and metastatic bladder cancer....
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Comparative analysis of the transcriptome of T2DM Bama mini-pigs with T2DM patients
ObjectiveTo compare the transcriptional differences between the T2DM-susceptible and T2DM-tolerant Bama mini-pigs and to determine the utility of...
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Nanoparticle-based vaccine development and evaluation against viral infections in pigs
Virus infections possess persistent health challenges in swine industry leading to severe economic losses worldwide. The economic burden caused by...
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Combination of novel intravesical xenogeneic urothelial cell immunotherapy and chemotherapy enhances anti-tumor efficacy in preclinical murine bladder tumor models
BackgroundImmune checkpoint inhibitors induce robust and durable responses in advanced bladder cancer (BC), but only for a subset of patients....
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Will Genetic Engineering Carry Xenotransplantation of Pig Islets to the Clinic?
Purpose of ReviewPorcine islets represent a potentially attractive beta-cell source for xenotransplantation into patients with type 1 diabetes, who...
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Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity
Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve repair or replacement has been the standard of care for...
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Updates on Corneal Xenotransplantation
Purpose of ReviewGlobally, the supply of donor cornea does not meet the demand in certain regions. Corneal xenotransplantation has been investigated...
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Intestinal microbiota has important effect on severity of hand foot and mouth disease in children
BackgroundThe incidence of hand foot and mouth disease (HFMD) has increased in recent years, making it a very common childhood illness worldwide. The...
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No evidence of enteric viral involvement in the new neonatal porcine diarrhoea syndrome in Danish pigs
BackgroundThe aim of this study was to investigate whether the syndrome New Neonatal Porcine Diarrhoea Syndrome (NNPDS) is associated with a viral...
