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DON in pediatric cerebral malaria, a phase I/IIA dose-escalation safety study: study protocol for a clinical trial
BackgroundDespite treatment with highly effective antimalarial drugs, malaria annually claims the lives of over half a million children under 5-years...
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Efficacy of DigiKnowItNews: Teen, a multimedia educational website for adolescents about pediatric clinical trials: study protocol for a randomized controlled trial
BackgroundPediatric research is crucial for the development of new scientific advancements, treatments, and therapies for adolescents. Yet relatively...
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Guidelines for reporting pediatric and child health clinical trial protocols and reports: study protocol for SPIRIT-Children and CONSORT-Children
BackgroundDespite the critical importance of clinical trials to provide evidence about the effects of intervention for children and youth, a paucity...
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Effectiveness of perioperative low-dose esketamine infusion for postoperative pain management in pediatric urological surgery: a prospective clinical trial
BackgroundPostoperative pain is common in pediatric urological surgery. The study assess the impact of perioperative intravenous infusion of low-dose...
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Health care impact of implementing a clinical pathway for acute care of pediatric concussion: a stepped wedge, cluster randomised trial
ObjectivesTo test the effects of actively implementing a clinical pathway for acute care of pediatric concussion on health care utilization and costs.
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Lung ultrasound and procalcitonin, improving antibiotic management and avoiding radiation exposure in pediatric critical patients with bacterial pneumonia: a randomized clinical trial
BackgroundPneumonia is a major public health problem with an impact on morbidity and mortality. Its management still represents a challenge. The aim...
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Success and complications in lumbar punctures of pediatric patients with leukemia: a study protocol for a randomized clinical crossover trial of a bioimpedance needle system versus conventional procedure
BackgroundAcute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children. At present, the long-term survival from pediatric...
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Custodiol versus blood cardioplegia in pediatric cardiac surgery: a randomized controlled trial
BackgroundBlood-based cardioplegia is the standard myocardial protection strategy in pediatric cardiac surgery. Custadiol...
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Prophylaxis for pediatric postoperative nausea and vomiting: a sco** review of clinical trials
PurposePostoperative nausea and vomiting (PONV) is common in pediatric patients undergoing general anesthesia, and clinicians seek prophylactic...
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Early coagulopathy after pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial
BackgroundTo estimate the incidence, risk factors, and impact on mortality and functional outcomes for early coagulopathy after the return of...
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Efficacy of 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) in high-risk pediatric retinal detachment; randomized clinical trial
BackgroundPediatric rhegmatogenous retinal detachments (PRRDs) are complex, rare occurrences and are often related to trauma or congenital...
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Head cooling wrap could suppress the elevation of core temperature after cardiac surgery during forced-air warming in a pediatric intensive care unit: a randomized clinical trial
PurposeThe main aim of the current trial was to explore our hypothesis that cooling head wraps lower the core temperature more effectively than ice...
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Prospective, randomized, double-blind, double-dummy, active-controlled, phase 3 clinical trial comparing the safety and efficacy of intranasal dexmedetomidine to oral midazolam as premedication for propofol sedation in pediatric patients undergoing magnetic resonance imaging: the MIDEX MRI trial
BackgroundChildren under 6 years who need magnetic resonance imaging usually require sedation to obtain best quality images, but the optimal sedation...
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Comparison of ultrasound-guided supraclavicular and costoclavicular brachial plexus blocks in pediatric patients: a randomized clinical trial
PurposeCostoclavicular brachial plexus block has been described recently as a new technique in adults and pediatric patients. In this study, we aimed...
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Severe pediatric COVID-19: a review from the clinical and immunopathophysiological perspectives
BackgroundCoronavirus disease 2019 (COVID-19) tends to have mild presentations in children. However, severe and critical cases do arise in the...
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In-person versus electronic screening for social risks among carers of pediatric inpatients: A mixed methods randomized trial
We aimed to compare disclosure of social risks according to self-report on an iPad versus face-to-face questions from a health professional and to...
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Pilot randomized controlled trial of restricted versus liberal crystalloid fluid management in pediatric post-operative and trauma patients
BackgroundIntravenous (IV) fluid therapy is essential in the treatment of critically ill pediatric surgery and trauma patients. Recent studies have...
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Mobile phone virtual reality game for pediatric home burn dressing pain management: a randomized feasibility clinical trial
BackgroundVirtual reality (VR) gaming is considered a safe and effective alternative to standard pain alleviation in the hospital. This study...
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Effect of intravenous induction with different doses of Esketamine combined with propofol and sufentanil on intraocular pressure among pediatric strabismus surgery: a randomized clinical trial
BackgroundIt is well-established that maintaining stable intraocular pressure (IOP) within the normal range during ophthalmic surgery is important....
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Oral midazolam vs. intranasal dexmedetomidine plus oral midazolam for sedation of pediatric outpatients: a double-blinded randomized controlled trial
BackgroundModerate to deep sedation is required for dental treatment of children with dental anxiety. Midazolam is the most commonly used sedative,...
