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Comparing efficacy of charged-particle therapy with brachytherapy in treatment of uveal melanoma
BackgroundUveal melanoma (UM) is the most common primary ocular tumour in adults. The most used eye-preserving treatments are charged-particle...
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Alpha Particle–Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
Critical advances in radionuclide therapy have led to encouraging new options for cancer treatment through the pairing of clinically useful...
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Imaging and dosimetry for alpha-particle emitter radiopharmaceutical therapy: improving radiopharmaceutical therapy by looking into the black box
Radiopharmaceutical therapy using α-particle emitting radionuclides (αRPT) is a novel treatment modality that delivers highly potent alpha-particles...
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Combined, yet separate: cocktails of carriers (not drugs) for actinium-225 α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers
AbstractAlpha-particle radionuclide-antibody conjugates are being clinically evaluated against solid tumors even when they moderately express the...
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Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): a retrospective multi-institutional study
PurposeTo evaluate the outcomes of particle therapy in cancer patients with cardiac implantable electronic devices (CIEDs).
Materials and methods ...
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Pre-clinical evaluation of biomarkers for the early detection of nephrotoxicity following alpha-particle radioligand therapy
PurposeCancer treatment with alpha-emitter-based radioligand therapies (α-RLTs) demonstrates promising tumor responses. Radiolabeled peptides are...
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Novel concept of “sequential particle radiotherapy” with atezolizumab plus bevacizumab for hepatocellular carcinoma with portal vein tumor thrombus
Owing to the high objective response rate of atezolizumab plus bevacizumab (Atez/Bev) for hepatocellular carcinoma (HCC), the concept of sequential...
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Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects
Magnetic particle imaging (MPI) is a novel quantitative imaging technique using the nonlinear magnetization behavior of magnetic nanoparticles (MNPs)...
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Therapeutic efficacy of an alpha-particle emitter labeled anti-GD2 humanized antibody against osteosarcoma—a proof of concept study
PurposeCurrent treatments for osteosarcoma (OS) have a poor prognosis, particularly for patients with metastasis and recurrence, underscoring an...
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Structural modifications toward improved lead-203/lead-212 peptide-based image-guided alpha-particle radiopharmaceutical therapies for neuroendocrine tumors
PurposeThe lead-203 ( 203 Pb)/lead-212 ( 212 Pb) elementally identical radionuclide pair has gained significant interest in the field of image-guided...
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Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy
Central nervous system (CNS) radiotoxicity remains a challenge in neuro-oncology. Dose distribution advantages of protons over photons have prompted...
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Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis
Surgical intervention is the first-line treatment in well-selected hepatocellular carcinoma (HCC) patients. However, only a few patients are suitable...
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Does particle radiation have superior radiobiological advantages for prostate cancer cells? A systematic review of in vitro studies
BackgroundCharged particle beams from protons to carbon ions provide many significant physical benefits in radiation therapy. However, preclinical...
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Hepatic infarction occurred after 125I particle stent treatment for hepatocellular carcinoma with portal vein tumor thrombus: A case report
BackgroundHepatic infarction is a rare liver condition. The purpose of this study is to report a case of hepatic infarction caused by thrombus...
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Stop**-power ratio of body tissues with updated effective energies and elemental I values for treatment planning of proton therapy and ion beam therapy with helium, carbon, oxygen, and neon ions
The stop**-power ratio (SPR) of body tissues relative to water depends on the particle energy and mean excitation energy ( I value) of the tissues....
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Stop**-power ratio of mouthpiece materials for charged-particle therapy in head and neck cancer
In this study, the stop**-power ratios (SPRs) of mouthpiece materials were measured and the errors in the predicted SPRs based on conversion table...
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Smart nanoparticles for cancer therapy
Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer...
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Review of clinical results of charged-particle therapy for esophageal cancer
Esophageal cancer is one of the common causes of cancer-related death. The treatment for esophageal cancer, particularly unresectable cases, is a...
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Particle filter-based parameter estimation algorithm for prognostic risk assessment of progression in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a malignant tumor that threatens human life and health. The development of a new NSCLC risk assessment model...
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Biological effects of cancer stem cells irradiated by charged particle: a systematic review of in vitro studies
PurposeThe existence of cancer stem cells (CSCs) is closely related to tumor recurrence, metastasis, and resistance to chemoradiotherapy. In...
