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Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
Neurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke,...
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Associations of Alzheimer's-related plasma biomarkers with cognitive decline in Parkinson's disease
BackgroundParkinson’s disease (PD) is associated with cognitive decline through multiple mechanisms, including Alzheimer’s disease (AD) pathology and...
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Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000–2022
BackgroundAlzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and...
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Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities
Dementia with Lewy bodies is the second most common cause of neurodegenerative dementia after Alzheimer's disease. Dementia with Lewy bodies can...
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PET/MR: Functional and Molecular Imaging of Neurological Diseases and Neurosciences
This book aims to summarize the research progress of integrated PET/MR brain function and molecular imaging, and more importantly, clinical...
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Early prediction of Alzheimer's disease using convolutional neural network: a review
In this paper, a comprehensive review on Alzheimer's disease (AD) is carried out, and an exploration of the two machine learning (ML) methods that...
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Effects of exercise mimetics as putative therapeutics on brain health, aging, and neurodegenerative diseases
There is growing evidence that an active lifestyle can benefit brain health, delay the onset of neurodegenerative diseases and aging, and improve...
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Exploring the potential of vagus nerve stimulation in treating brain diseases: a review of immunologic benefits and neuroprotective efficacy
The vagus nerve serves as a critical connection between the central nervous system and internal organs. Originally known for its effectiveness in...
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Anti-Amyloid Monoclonal Antibodies are Transformative Treatments that Redefine Alzheimer's Disease Therapeutics
Two anti-amyloid monoclonal antibodies (MABs)—lecanemab (Leqembi ® ) and aducanumab (Aduhelm ® )—have been approved in the USA for the treatment of...
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Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit
Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra...
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Application of machine learning in measurement of ageing and geriatric diseases: a systematic review
BackgroundAs the ageing population continues to grow in many countries, the prevalence of geriatric diseases is on the rise. In response, healthcare...
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Effective dosage and mode of exercise for enhancing cognitive function in Alzheimer's disease and dementia: a systematic review and Bayesian Model-Based Network Meta-analysis of RCTs
ObjectiveResearch the dose–response relationship between overall and certain types of exercise and cognitive function in older adults with...
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Natural products in the management of neurodegenerative diseases
Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of...
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Autoregulation: mediators and renin–angiotensin system in diseases and treatments
BackgroundHemodynamic regulation is a substantial part of the physiological integrity of the human body. It is based on the delivery of proper blood...
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Glial cell transplant for brain diseases: the supportive saviours?
The incidence of brain diseases in humans is increasing as we experience a worldwide ageing of the population. Treatment for such diseases is still...
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Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies
Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or...
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Causal relationships between type 1 diabetes mellitus and Alzheimer’s disease and Parkinson’s disease: a bidirectional two-sample Mendelian randomization study
BackgroundPrevious compelling evidence suggests an association between Type 2 diabetes (T2D) and neurodegenerative diseases. However, it remains...
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Brain pathological changes during neurodegenerative diseases and their identification methods: How does QSM perform in detecting this process?
The presence of iron is essential for many biological processes in the body. But sometimes, for various reasons, the amount of iron deposition in...
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Significance of cerebral amyloid angiopathy and other co-morbidities in Lewy body diseases
Lewy body dementia (LBD) and Parkinson's disease-dementia (PDD) are two major neurocognitive disorders with Lewy bodies (LB) of unknown etiology....
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Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes
Parkinson´s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Aggravation of symptoms is...
