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Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and...
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Exercise following joint distraction inhibits muscle wasting and delays the progression of post-traumatic osteoarthritis in rabbits by activating PGC-1α in skeletal muscle
ObjectiveMuscle wasting frequently occurs following joint trauma. Previous research has demonstrated that joint distraction in combination with...
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Expressions of mitochondria-related genes in pregnant women with subclinical hypothyroidism, and expressions of miRNAs in maternal and cord blood
BackgroundSubclinical hypothyroidism in pregnancy and definition by upper thyrotropin (TSH) cutoff are controversial. As mitochondria are influenced...
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RORA alleviates LPS-induced apoptosis of renal epithelial cells by promoting PGC-1α transcription
ObjectiveTo explore the effect of RORA on LPS-induced renal epithelial cell apoptosis and the underlying mechanism.
MethodsLPS-treated HK-2 cells...
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PGC-1: a key regulator in bone homeostasis
Peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) is an inducible co-regulator of nuclear receptors and is involved in a wide...
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L-citrulline attenuates lipopolysaccharide-induced inflammatory lung injury in neonatal rats
BackgroundPrenatal or postnatal lung inflammation and oxidative stress disrupt alveolo-vascular development leading to bronchopulmonary dysplasia...
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MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα
BackgroundMetabolic abnormalities have been implicated as a causal event in diabetic cardiomyopathy (DCM). However, the mechanisms underlying cardiac...
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Yixin Ningshen Tablet Alleviates Comorbidity of Myocardial Infarction and Depression by Enhancing Myocardial Energy Metabolism and Increasing Availability of Monoamine Neurotransmitter
ObjectiveTo investigate the therapeutic effect of Yixin Ningshen Tablet (YXNS) on comorbidity of myocardial infarction (MI) and depression in rats...
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Mitochondrial quality control in human health and disease
Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their...
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Mitochondrial dysfunction and drug targets in multiple myeloma
Multiple myeloma (MM) is the second most common hematological cancer that has no cure. Although currently there are several novel drugs, most MM...
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Asprosin: its function as a novel endocrine factor in metabolic-related diseases
Background and purposeAsprosin was discovered as a new endocrine hormone originating from fibrillin-1 cleavage that plays a crucial role in various...
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Therapy of traumatic brain injury by modern agents and traditional Chinese medicine
Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is...
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Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis
Background and aimPost-traumatic osteoarthritis (PTOA) is a subtype of osteoarthritis (OA). Exercise may produce and release the myokine irisin...
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Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS
BackgroundExcessive production of androgen drives oxidative stress (OS) and inflammasome activation in ovarian granulosa cells (GCs). Therefore, the...
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Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals
Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor for suicidality. Recent evidence shows that accelerated...
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The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets
Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular cartilage. Mounting studies have revealed that disruption of...
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Metabolism, metabolites, and macrophages in cancer
Tumour-associated macrophages (TAMs) are crucial components of the tumour microenvironment and play a significant role in tumour development and drug...
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Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway
ObjectiveDiabetic nephropathy is one of the most important microvascular complications of diabetes, which mainly refers to glomerular capillary...
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ERRα: unraveling its role as a key player in cell migration
Cell migration is essential throughout the life of multicellular organisms, and largely depends on the spatial and temporal regulation of...
