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An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?
BackgroundThe need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research...
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Poorer aging trajectories are associated with elevated serotonin synthesis capacity
The dorsal raphe nucleus (DRN) is one of the earliest targets of Alzheimer’s disease-related tau pathology and is a major source of brain serotonin....
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International consensus on the use of tau PET imaging agent 18F-flortaucipir in Alzheimer’s disease
PurposePositron emission tomography (PET) with the first and only tau targeting radiotracer of 18 F-flortaucipir approved by FDA has been...
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Improving CT-guided transthoracic biopsy diagnostic yield of lung masses using intraprocedural CT and prior PET/CT fusion imaging
ObjectiveThe purpose of this study was to evaluate the usefulness of intraprocedural CT and prior PET/CT fusion imaging in improving the diagnostic...
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[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma
BackgroundBoth [ 18 F]FDOPA (FDOPA) and [ 68 Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL)....
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Impact of simulated reduced injected dose on the assessment of amyloid PET scans
PurposeTo investigate the impact of reduced injected doses on the quantitative and qualitative assessment of the amyloid PET tracers [ 18 F]flutemetamo...
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Associations among locus coeruleus catecholamines, tau pathology, and memory in aging
The locus coeruleus (LC) is the brain’s major source of the neuromodulator norepinephrine, and is also profoundly vulnerable to the development of...
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Distinct amyloid and tau PET signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type
We aimed to investigate the amyloid and tau PET imaging signatures of patients with amnestic syndrome of the hippocampal type (ASHT) and study their...
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Spatial normalization and quantification approaches of PET imaging for neurological disorders
Quantification approaches of positron emission tomography (PET) imaging provide user-independent evaluation of pathophysiological processes in living...
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Yield of non-invasive imaging in MRI-negative focal epilepsy
ObjectiveThe absence of MRI-lesion reduces considerably the probability of having an excellent outcome (International League Against Epilepsies...
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Characterisation of a novel [18F]FDG brain PET database and combination with a second database for optimising detection of focal abnormalities, using focal cortical dysplasia as an example
BackgroundBrain [ 18 F]FDG PET is used clinically mainly in the presurgical evaluation for epilepsy surgery and in the differential diagnosis of...
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Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies
PurposeWe hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more...
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Age-related increase of monoamine oxidase B in amyloid-negative cognitively unimpaired elderly subjects
ObjectiveMonoamine oxidase B (MAO-B) is highly abundant in reactive astrocytes and upregulated in neuroinflammatory processes. However, the...
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Validation of quantitative assessment of florbetaben PET scans as an adjunct to the visual assessment across 15 software methods
PurposeAmyloid positron emission tomography (PET) with [ 18 F]florbetaben (FBB) is an established tool for detecting Aβ deposition in the brain in...
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[18F]SynVesT-1 and [18F]FDG quantitative PET imaging in the presurgical evaluation of MRI-negative children with focal cortical dysplasia type II
PurposeMRI-negative children with focal cortical dysplasia type II (FCD II) are one of the most challenging cases in surgical epilepsy management. We...
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Cortical abnormalities of synaptic vesicle protein 2A in focal cortical dysplasia type II identified in vivo with 18F-SynVesT-1 positron emission tomography imaging
PurposeThe loss of synaptic vesicle glycoprotein 2A (SV2A) is well established as the major correlate of epileptogenesis in focal cortical dysplasia...
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CERMEP-IDB-MRXFDG: a database of 37 normal adult human brain [18F]FDG PET, T1 and FLAIR MRI, and CT images available for research
We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants...
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Change in brain activation after transcranial pulsed electromagnetic fields in treatment-resistant depression
BackgroundPreliminary evidence suggests antidepressant effects of transcranial pulsed electromagnetic fields (tPEMF). However, the precise mechanism...
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At-home Administration of Gantenerumab by Care Partners to People with Early Alzheimer’s Disease: Feasibility, Safety and Pharmacodynamic Impact
BackgroundMonoclonal antibodies that target amyloid-beta and remove amyloid plaques can slow cognitive and functional decline in early Alzheimer’s...
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First clinical assessment of [18F]MC225, a novel fluorine-18 labelled PET tracer for measuring functional P-glycoprotein at the blood–brain barrier
Objective5-(1-(2-[ 18 F]fluoroethoxy))-[3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propyl]-5,6,7,8-tetrahydronaphthalen ([ 18 F]MC225) is a...
