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Building an effective medicines optimisation model: a health system approach
This commentary narrates on the building of an effective and innovative medicines optimisation model. It discusses the essential features, emphasizes...
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Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications
BackgroundHistone deacetylase 6 (HDAC6) is an emerging target for the treatment and diagnosis of proteinopathies. [ 18 F]FSW-100 was recently...
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Evaluating a pre-surgical health optimisation programme: a feasibility study
BackgroundHealth optimisation programmes are increasingly popular and aim to support patients to lose weight or stop smoking ahead of surgery, yet...
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Develo** a novel optimisation approach for kee** heterogeneous diets healthy and within planetary boundaries for climate change
Background and objectivesCurrent dietary habits have substantial negative impacts on the health of people and the planet. This study aimed to develop...
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Preoperative assessment and optimisation prior to planned aortic aneurysm repair: a UK survey examining current practice and attitudes of vascular surgeons and vascular anaesthetists
BackgroundThe majority of those diagnosed with aortic aneurysm in the UK are older, multi-morbid patients. Decision-making as to who may benefit from...
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Region of birth differences in healthcare navigation and optimisation: the interplay of racial discrimination and socioeconomic position
BackgroundWhile a large body of research has documented socioeconomic and migrant inequities in the effective use of healthcare services, the reasons...
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Ageing with HIV: Medicine Optimisation Challenges and Support Needs for Older People Living with HIV: A Systematic Review
BackgroundOlder people living with HIV (PLWH) are at increased risks of co-morbidities and polypharmacy. However, little is known about factors...
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A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients
BackgroundCognitive decline is common in older people. Numerous studies point to the detrimental impact of polypharmacy and inappropriate medication...
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The development and validation of a medicines optimisation tool to protect the physical health of people with severe mental illness (OPTIMISE)
BackgroundThe life expectancy of people with severe mental illness (SMI) is shorter than those without SMI, with multimorbidity and poorer physical...
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Optimisation of protection in the medical exposure of recurrent adult patients due to computed tomography procedures: development of recurrent exposures reference levels
ObjectivesTo assess the incidence (1 year) and the cumulative incidence (3 years) of the condition of patients accruing cumulative effective doses...
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Optimisation of the DNA dipstick as a rapid extraction method for Schistosoma japonicum in infected mice samples and spiked human clinical samples
BackgroundSchistosomiasis remains a public health issue and the need for accurate and affordable diagnostics is crucial in the elimination of the...
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ECG optimisation for CRT systems in the era of automatic algorithms: a comprehensive review
Cardiac resynchronisation therapy (CRT) may fail in up to one third of patients, mainly due to anatomical and procedural issues. In the daily...
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Hospital physicians’ and older patients’ agreement with individualised STOPP/START-based medication optimisation recommendations in a clinical trial setting
ObjectiveTo evaluate the agreement of hospital physicians and older patients with individualised STOPP/START-based medication optimisation...
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Vaximap: route optimisation for housebound vaccination
During the United Kingdom’s Covid-19 vaccination campaign, general practitioners (GPs) have held responsibility for vaccinating housebound patients....
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Optimisation of vitamin D status in global populations
AbstractVitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary...
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Pre-treatment optimisation with pulmonary rehabilitation of elderly lung cancer patients with frailty for surgery
ObjectiveFrailty develops as a result of age-related decline in many physiological systems and is associated with increased vulnerability to adverse...
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Optimisation of b-values for the accurate estimation of the apparent diffusion coefficient (ADC) in whole-body diffusion-weighted MRI in patients with metastatic melanoma
ObjectiveTo establish optimised diffusion weightings (‘ b -values’) for acquisition of whole-body diffusion-weighted MRI (WB-DWI) for estimation of...
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Optimisation of medication reconciliation using queueing theory: a computer experiment
BackgroundMedication reconciliation (MedRec) in hospitals is an important tool to enhance the continuity of care, but completing MedRec is...
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Commissioner, clinician, and patient experiences of a pre‐surgical health optimisation programme – a qualitative study
BackgroundHealth optimisation programmes are an increasingly popular policy intervention that aim to support patients to lose weight or stop smoking...
