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Effect of prebiotic oligosaccharides on bowel habit and the gut microbiota in children with functional constipation (Inside study): study protocol for a randomised, placebo-controlled, multi-centre trial
BackgroundFunctional constipation (FC) in children is a common gastrointestinal disorder with a worldwide-pooled prevalence of 9.5%. Complaints...
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Human milk oligosaccharides promote intestinal epithelium regeneration independent of the microbiota during necrotizing enterocolitis
PurposeNecrotizing enterocolitis (NEC) is a severe intestinal disease primarily affecting premature infants, marked by impaired epithelial...
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Associations between human milk oligosaccharides and infant growth in a Bangladeshi mother–infant cohort
BackgroundWe aimed to estimate associations between human milk oligosaccharides (HMOs) and infant growth (length-for-age (LAZ) and weight-for-length...
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Infant formulas with synthetic oligosaccharides and respective marketing practices: Position Statement of the German Society for Child and Adolescent Medicine e.V. (DGKJ), Commission for Nutrition
Human milk contains more than 150 different oligosaccharides, which together are among to the quantitatively predominant solid components of breast...
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Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial
BackgroundThis trial aimed to evaluate the anti-obesity effects and safety of Neoagaro-oligosaccharides (NAOs) in humans in a 16 week, randomized,...
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Role of xylo-oligosaccharides in relieving complications accompanied to carbimazole drug administrated with 1% saline in female Wistar rats
BackgroundAmeliorating the complications of pharmaceutical drugs by natural compounds or probiotics is now a medical strategy. The anti-thyroid drug...
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Real-world evidence study on tolerance and growth in infants fed an infant formula with two human milk oligosaccharides vs mixed fed and exclusively breastfed infants
IntroductionHuman milk oligosaccharides (HMOs) are important components of human milk having diverse functions in the development of infants....
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Concentrations of oligosaccharides in human milk and child growth
BackgroundThe relationship between human milk oligosaccharides (HMO) and child growth has been investigated only insufficiently with ambiguous...
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Infant formula containing bovine milk-derived oligosaccharides supports age-appropriate growth and improves stooling pattern
BackgroundAdding bovine milk-derived oligosaccharides (MOS) enhances the oligosaccharide profile of infant formula. This study aimed to evaluate the...
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Chito-oligosaccharides and macrophages have synergistic effects on improving ovarian stem cells function by regulating inflammatory factors
BackgroundChronic low-grade inflammation and ovarian germline stem cells (OGSCs) aging are important reasons for the decline of ovarian reserve...
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Sialylated human milk oligosaccharides program cognitive development through a non-genomic transmission mode
Breastmilk contains bioactive molecules essential for brain and cognitive development. While sialylated human milk oligosaccharides (HMOs) have been...
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Human milk oligosaccharides, infant growth, and adiposity over the first 4 months of lactation
BackgroundThe relationship between human milk oligosaccharides (HMOs) and infant growth and adiposity is not fully understood and comprehensive...
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A new UHPLC-MS/MS method for the screening of urinary oligosaccharides expands the detection of storage disorders
BackgroundOligosaccharidoses are storage disorders due to enzymatic defects involved in the breakdown of the oligosaccharidic component of...
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Sialylated human milk oligosaccharides prevent intestinal inflammation by inhibiting toll like receptor 4/NLRP3 inflammasome pathway in necrotizing enterocolitis rats
BackgroundNecrotizing enterocolitis (NEC) remains a fatal gastrointestinal disorder in neonates and has very limited therapeutic options. Sialylated...
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The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling
BackgroundNecrotizing enterocolitis (NEC) develops through exaggerated toll-like receptor 4 (TLR4) signaling in the intestinal epithelium. Breast...
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Necrotizing enterocolitis: recent advances in treatment with translational potential
Necrotizing enterocolitis (NEC) is one of the most prevalent and devastating gastrointestinal disorders in neonates. Despite advances in neonatal...
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Anti-prostate cancer mechanism of black ginseng during the "nine steaming and nine sun-drying" process based on HPLC analysis combined with vector space network pharmacology
HPLC analysis determined six small-molecule organic acids, maltol, 5-hydroxymethylfurfural (5-HMF), 17 ginsenosides, four oligosaccharides, and 20...
