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Oligo-residual disease in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer: incidence, pattern of failure, and clinical value of local consolidative therapy
ObjectivesTo investigate the feasibility and potential clinical value of local consolidative therapy (LCT) in PD-1/PD-L1 inhibitor-treated metastatic...
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Local Therapeutics for the Treatment of Oligo Metastatic Prostate Cancer
Purpose of ReviewMetastatic prostate cancer remains universally lethal. Although de-novo metastatic prostate cancer was historically managed with...
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Oligo metastatic renal cell carcinoma: stereotactic body radiation therapy, if, when and how?
Background and purposeRenal cell carcinoma (RCC) has traditionally been considered radioresistant with a limited role for conventional fractionation...
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Update to a randomized controlled trial of lutetium-177-PSMA in Oligo-metastatic hormone-sensitive prostate cancer: the BULLSEYE trial
BackgroundThe BULLSEYE trial is a multicenter, open-label, randomized controlled trial to test the hypothesis if 177 Lu-PSMA is an effective...
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Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial
To evaluate the safety and efficacy of neoadjuvant radiohormonal therapy for oligometastatic prostate cancer (OMPC), we conducted a 3 + 3 dose...
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OLIGO-AIRO: a national survey on the role of radiation oncologist in the management of OLIGO-metastatic patients on the behalf of AIRO
In the last years, several evidences demonstrated the role of stereotactic body radiotherapy (SBRT) in the oligometastatic disease and the...
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Clinical experience of consolidative radiotherapy for localized metastatic non-small cell lung cancer who showed favorable tumor response after systemic treatment
BackgroundOur study has aimed to assess the effects of consolidative high-dose radiotherapy on clinical outcomes in patients with localized...
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The pattern of failure after Stereotactic Radiation Therapy (SRT) for oligo-metastases: predictive factors for poly-progression
PurposePatients with oligo-metastatic disease (OMD) can be safely treated with Stereotactic Radiation Therapy (SRT). Further disease progression is...
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Radiotherapy for Advanced Esophageal Cancer: from Palliation to Curation
Esophageal cancer is a global health problem, which is 7th most common and 6th most deadly cancer. It has been the era of immuno-oncology for...
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Study protocol and preliminary results from a mono-centric cohort within a trial testing stereotactic body radiotherapy and abiraterone (ARTO-NCT03449719)
BackgroundARTO trial was designed to evaluate the difference in terms of outcomes between patients affected by oligo metastatic castrate resistant...
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PSMA PET/CT imaging for biochemical recurrence of prostate cancer after radiotherapy: is it necessary to review the Phoenix criteria?
PurposePSMA positron emission tomography (PET)/CT imaging and new systemic treatment strategies have been recently implemented in the routine care of...
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Pattern of recurrence after stereotactic body radiotherapy for para-aortic oligo-recurrent prostate cancer, a multicentric analysis
BackgroundM1a disease represents an intermediate status between loco-regional relapse and bone metastatic disease. Metastasis directed therapy (MDT),...
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Prognostic impact of bone metastases detected by 18F-DOPA PET in patients with metastatic midgut neuroendocrine tumors
ObjectivesBone metastases (BM) may influence negatively the prognosis of midgut neuroendocrine tumors (NET). The diagnostic sensitivity of 18 F-DOPA...
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The value of radical radiotherapy in the primary tumor of newly diagnosed oligo-metastatic nasopharyngeal carcinoma patients
BackgroundTo explore the efficacy and patterns of treatment failure of radical radiotherapy in newly diagnosed oligo-metastatic nasopharyngeal...
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Influence of localization of PSMA-positive oligo-metastases on efficacy of metastasis-directed external-beam radiotherapy—a multicenter retrospective study
PurposeApproximately 40–70% of biochemically persistent or recurrent prostate cancer (PCa) patients after radical prostatectomy (RPE) are...
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Recurrence Pattern, Treatment Modalities, and Prognostic Factors After Definitive Chemoradiotherapy for Recurrent Esophageal Cancer
BackgroundRecurrent esophageal cancer (EC) has a poor prognosis. However, the recurrence patterns and therapeutic outcomes after definitive...
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MR-guided prostate SBRT in prostate cancer patients with low-volume metastatic disease
BackgroundRecent data have found an overall survival benefit from prostate-directed radiotherapy in patients with low-volume metastatic prostate...
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Cerebral Metastases in Breast Cancer Patients: a Narrative Review
Purpose of the ReviewThe purpose of this review is to address the rising incidence of cerebral metastases in breast cancer patients, which is now...
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International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape
BackgroundMany gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months...
