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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved...
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Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma
Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease...
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Notch signaling pathway: a new target for neuropathic pain therapy
The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the...
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Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading...
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The Notch signaling pathway: a potential target for cancer immunotherapy
Dysregulation of the Notch signaling pathway, which is highly conserved across species, can drive aberrant epigenetic modification, transcription,...
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NOTCH pathway mutation contributes to inferior prognosis in HBV-infected chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) patients with hepatitis B virus (HBV) infection have a poor prognosis, underlying mechanism remains unclear. NOTCH...
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Audiological Profile of a Rare Case with 1 kHz Notch Audiogram
A notch is defined as the frequency point at which hearing loss is greater than 15 dB when compared to one octave above and below. C3 dip or 1 kHz...
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Anatomy of the iliopsoas notch and its relationship with morphology of the proximal femur
PurposeDiscrepancy between the morphology of the acetabular margin and the design of hemispheric acetabular cups used in total hip arthroplasty may...
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Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome
PurposeThe mechanisms that control inflammation in scrub typhus are not fully elucidated. The Notch pathways are important regulators of inflammation...
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PMCT-based sex determination using posterior segment of greater sciatic notch in North Indian population
BackgroundDigital tools, which offer superior accuracy compared to manual metrics, utilize radiological images for noninvasive data collection,...
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Notch signaling regulates a metabolic switch through inhibiting PGC-1α and mitochondrial biogenesis in dedifferentiated liposarcoma
Human dedifferentiated liposarcoma (DDLPS) is a rare but lethal cancer with no driver mutations being identified, hampering the development of...
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Notch appearance as a novel radiological predictor of transient expansion and good outcome of expanding schwannoma after radiotherapy
ObjectivesSchwannoma expansion after radiotherapy has not been well-studied despite the clinical importance of distinguishing transient increase from...
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Notch ratio in pulmonary flow predicts long-term survival after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
BackgroundAssessment of the pattern of the RV outflow tract Doppler provides insights into the hemodynamics of chronic thromboembolic pulmonary...
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Epigenetically dysregulated NOTCH-Delta-HES signaling cascade can serve as a subtype classifier for acute lymphoblastic leukemia
The NOTCH-Delta-HES signaling cascade is regarded as a double-edged sword owing to its dual tumor-suppressor and oncogenic roles, in different...
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Notch signaling regulates Th17 cells differentiation through PI3K/AKT/mTORC1 pathway and involves in the thyroid injury of autoimmune thyroiditis
PurposeAutoimmune Thyroiditis (AIT) is the most common thyroid disease; however, there were no measures to prevent the progression of the disease....
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Variability in the distance between the suprascapular notch with the spine of the scapulae and the acromion
IntroductionThe suprascapular notch lies in the superior border of the scapula and is a passageway for the suprascapular nerve that is sensory to the...
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The Dicrotic Notch: Mechanisms, Characteristics, and Clinical Correlations
Purpose of ReviewThe dicrotic notch (DN) has long been considered a marker of arterial stiffness and compliance. Herein, we explored the recent...
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Jagged1 contained in MSC-derived small extracellular vesicles promotes squamous differentiation of cervical cancer by activating NOTCH pathway
PurposeCervical cancer is the fourth most common cancer in women and poses a major threat to women's health, urgently requiring new treatment methods.
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Notch signaling pathway: architecture, disease, and therapeutics
The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved...
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SPOPL induces tumorigenicity and stemness in glioma stem cells by activating Notch signaling
ObjectiveRecent studies have increasingly shown that glioma stem cells (GSCs) are extremely important for develo** and treating glioblastoma...
