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Plasma levels of neurogenic inflammation related neuropeptides in pediatric patients with community-acquired pneumonia and their potential diagnostic value in distinguishing viral and bacterial pneumonia
Neurogenic inflammation is involved in the development and progression of respiratory inflammatory diseases. However, its role in community-acquired...
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Analysis of Clinical Characteristics and Neuropeptides in Patients with Dry Eye with and without Chronic Ocular Pain after FS-LASIK
IntroductionChronic ocular pain, particularly prevalent in patients with dry eye disease and post-femtosecond laser-assisted laser in situ...
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Cutaneous neuropeptides: the missing link between psychological stress and chronic inflammatory skin disease?
A “brain-skin” connection has been long been observed between chronic stress and chronic inflammatory skin disease including urticaria, psoriasis,...
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Circulating levels of ghrelin, galanin, and orexin-A orexigenic neuropeptides in obstructive sleep apnea syndrome
PurposeThe orexigenic peptides, ghrelin, galanin, and orexin-A, have an important role in food intake and energy homeostasis and regulate the higher...
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Low Electrical Resistance Properties of Acupoints: Roles of NOergic Signaling Molecules and Neuropeptides in Skin Electrical Conductance
Early studies from several independent laboratories demonstrated that acupoints possess the characteristics of low electrical resistance. New devices...
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Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures
Schizophrenia (SZ) is a serious mental illness and neuropsychiatric brain disorder with behavioral symptoms that include hallucinations, delusions,...
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Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of sensory neurons with their peripheral and central...
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Insulin eye drops improve corneal wound healing in STZ-induced diabetic mice by regulating corneal inflammation and neuropeptide release
IntroductionIn recent years, insulin eye drops have attracted increasing attention from researchers and ophthalmologists. The aim of this study was...
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The airway neuro-immune axis as a therapeutic target in allergic airway diseases
Recent evidence has increasingly underscored the importance of the neuro-immune axis in mediating allergic airway diseases, such as allergic asthma...
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Inflammatory profile of keratoconic corneal epithelium
BackgroundRecent studies have presented inflammatory features on keratoconus (KC) and many inflammatory markers are described in the tears of...
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The brain–bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism
The brain–bone axis has emerged as a captivating field of research, unveiling the intricate bidirectional communication between the central nervous...
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Cracking the Code: The Role of Peripheral Nervous System Signaling in Fracture Repair
Purpose of ReviewThe traditionally understated role of neural regulation in fracture healing is gaining prominence, as recent findings underscore the...
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Alterations of serum neuropeptide levels and their relationship to cognitive impairment and psychopathology in male patients with chronic schizophrenia
Serum neuropeptide levels may be linked to schizophrenia (SCZ) pathogenesis. This study aims to examine the relation between five serum neuropeptide...
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Mechanisms of neuromodulatory volume transmission
A wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs...
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Hallmarks of peripheral nerve function in bone regeneration
Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the crosstalk between bone and...
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Excimer light effect on neurogenic inflammation in active versus stable psoriasis lesions
Neurogenic inflammation, mediated by T helper 17 cell (Th17) and neurons that release neuropeptides such as substance P (SP), is thought to play a...
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Immune Competence and Pain: A Narrative Review
Purpose of ReviewThis review aims to summarize current knowledge on the pathophysiology of pain and the role of neuro-immune crosstalk in the...
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Trigeminal ganglion itself can be a viable target to manage trigeminal neuralgia
Excruciating trigeminal neuralgia (TN) management is very difficult and severely affects the patient’s quality of life. Earlier studies have shown...
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Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat
BackgroundMonoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) are effective in the prevention of chronic...
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Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in cardiovascular diseases. Here, we question whether LPA...
