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Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia
Tandem repeat expansions (TREs) are associated with over 60 monogenic disorders and have recently been implicated in complex disorders such as cancer...
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Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis
Recent studies have shown that cellular levels of polyamines (PAs) are significantly altered in neurodegenerative diseases. Evidence from in vivo ...
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Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling
BackgroundPhelan–McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and...
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Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice
Chronic stress has become a predominant factor associated with a variety of psychiatric disorders, such as depression and anxiety, in both human and...
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Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits
In the mammalian brain information processing and storage rely on the complex coding and decoding events performed by neuronal networks. These...
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Friend or foe: role of pathological tau in neuronal death
Neuronal death is one of the most common pathological hallmarks of diverse neurological diseases, which manifest varying degrees of cognitive or...
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Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
BackgroundThe channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the...
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Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release
PurposeSome evidence that non-steroidal anti-inflammatory drugs have neuroprotective effects indicates their potential for use in a new field....
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Analysis of human neuronal cells carrying ASTN2 deletion associated with psychiatric disorders
Recent genetic studies have found common genomic risk variants among psychiatric disorders, strongly suggesting the overlaps in their molecular and...
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ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
ABCA7 loss-of-function variants are associated with increased risk of Alzheimer’s disease (AD). Using ABCA7 knockout human iPSC models generated with...
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Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress
Early life stress (ELS) is associated with the later development of schizophrenia. In the rodent model, the maternal separation (MS) stress may...
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The impact of adult neurogenesis on affective functions: of mice and men
In most mammals, new neurons are not only produced during embryogenesis but also after birth. Soon after adult neurogenesis was discovered, the...
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Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity
Functional output of the hippocampus, a brain region subserving memory function, depends on highly orchestrated cellular and molecular processes that...
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Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder
Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction...
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The role of TSC1 and TSC2 proteins in neuronal axons
Tuberous Sclerosis Complex 1 and 2 proteins, TSC1 and TSC2 respectively, participate in a multiprotein complex with a crucial role for the proper...
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Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration
The diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological...
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Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
BackgroundNeurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus...
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Radioprotective potential of probiotics against gastrointestinal and neuronal toxicity: a preclinical study
PurposeRadiotherapy is a critical component of cancer treatment, along with surgery and chemotherapy. Approximately, 90% of cancer patients...
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Modulatory effect of olanzapine on neuronal nitric oxide synthase (nNOS) expression in the rat striatum
Nitric oxide (NO) has been thought to be a novel factor involved in the mechanisms of mental disorders pathogenesis for quite some time. However,...
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Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning
The brain’s ability to associate threats with external stimuli is vital to execute essential behaviours including avoidance. Disruption of this...
