Search
Search Results
-
China Alzheimer’s Disease and Neurodegenerative Disorder Research (CANDOR) -A Prospective Cohort Study for Alzheimer’s Disease and Vascular Cognitive Impairment
BackgroundAlzheimer’s disease (AD) and vascular cognitive impairment (VCI) are the two main causes of dementia. AD and VCI share similar symptoms of...
-
Natural products in the management of neurodegenerative diseases
Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of...
-
Utilizing neurodegenerative markers for the diagnostic evaluation of amyotrophic lateral sclerosis
BackgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive deterioration of upper and lower motor...
-
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive...
-
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome...
-
Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases
Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the...
-
Functional connectivity changes in neurodegenerative biomarker-positive athletes with repeated concussions
Multimodal biomarkers may identify former contact sports athletes with repeated concussions and at risk for dementia. Our study aims to investigate...
-
Insights into AlphaFold’s breakthrough in neurodegenerative diseases
Neurodegenerative diseases (ND) are disorders of the central nervous system (CNS) characterized by impairment in neurons’ functions, and complete...
-
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the...
-
Detection of episodic nocturnal hypercapnia in patients with neurodegenerative disorders
PurposeEpisodic nocturnal hypercapnia (eNH) in transcutaneous carbon dioxide pressure (PtcCO 2 ) corresponding to rapid eye movement sleep...
-
Applications of brain-computer interfaces in neurodegenerative diseases
Brain-computer interfaces (BCIs) provide the central nervous system with channels of direct communication to the outside world, without having to go...
-
Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases
Previous observational investigations suggest that structural and diffusion imaging-derived phenotypes (IDPs) are associated with major...
-
Targeting NLRP3 inflammasome for neurodegenerative disorders
Neuroinflammation is a key pathological feature in neurological diseases, including Alzheimer’s disease (AD). The nucleotide-binding domain...
-
CSF-based liquid biopsy pointing to a diagnosis of diffuse glioma in a patient with supposed neurodegenerative disorder
IntroductionThe differential diagnosis of brain diseases becomes challenging in cases where imaging is not sufficiently informative, and surgical...
-
From Bench to Bedside: Unveiling the Effects of Phloroglucinol as a Promising Neuroprotective Agent in the Battle Against Neurodegenerative Disorders
Purpose of ReviewPhloroglucinol (PG) is a potent secondary metabolite found in various organisms, with extensive applications in medicine since its...
-
Modulation of Mitochondrial Function as a Therapeutic Strategy for Neurodegenerative Diseases
Despite recent FDA approval of anti-amyloid antibodies for Alzheimer’s Disease, strategies that target early molecular mechanisms and could delay or...
-
COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study
Emerging evidence has suggested a close correlation between COVID-19 and neurodegenerative disorders. However, whether there exists a causal...
-
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside...
-
SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders
With the increase in life expectancy, the incidence of neurodegenerative disorders and their impact worldwide has been increasing in recent years....
-
Functional brain networks in the evaluation of patients with neurodegenerative disorders
Network analytical tools are increasingly being applied to brain imaging maps of resting metabolic activity (PET) or blood oxygenation-dependent...
