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Intravenous misuse of slow-release oral morphine capsules: how much morphine is injected?
BackgroundThe injection of morphine from morphine sulfate capsules containing sustained-release microbeads (Skenan®) is a practice frequently...
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Treadmill exercise training inhibits morphine CPP by reversing morphine effects on GABA neurotransmission in D2-MSNs of the accumbens-pallidal pathway in male mice
Relapse is a major challenge in the treatment of drug addiction, and exercise has been shown to decrease relapse to drug seeking in animal models....
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People who inject oral morphine favor experimentation with injectable opioid substitution
BackgroundThe French Addictovigilance network has observed the existence of the intravenous use of oral morphine capsules among people suffering from...
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Morphine concentrations in fatalities after palliative treatment of acute burn injury
The evaluation of a morphine concentration in postmortem blood is routine for a forensic toxicologist. We here report three fatal cases where we...
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Comparison of intrathecal low-dose bupivacaine and morphine with intravenous patient control analgesia for postoperative analgesia for video-assisted thoracoscopic surgery
BackgroundThoracoscopic surgical techniques continue to advance, yet the intensity of postoperative pain remains significant, impeding swift patient...
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Clinical effect of rectus sheath block compared to intrathecal morphine injection for minimally invasive colorectal cancer surgery: a propensity score–matched study
PurposeTo evaluate the postoperative outcomes of a multimodal perioperative pain management protocol with rectus sheath blocks (RSBs) or intrathecal...
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Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA)
BackgroundIn emergency medicine, pain is a frequent reason for consultation. However, there is a great variation in its management which is often...
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Different projection neurons of basolateral amygdala participate in the retrieval of morphine withdrawal memory with diverse molecular pathways
Context-induced retrieval of drug withdrawal memory is one of the important reasons for drug relapses. Previous studies have shown that different...
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Comparing the efficacy of intravenous morphine versus ibuprofen or the combination of ibuprofen and acetaminophen in patients with closed limb fractures: a randomized clinical trial
IntroductionThis study aims to investigate the effectiveness of intravenous ibuprofen or intravenous ibuprofen plus acetaminophen compared to...
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Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations
Disrupted sleep is a symptom of many psychiatric disorders, including substance use disorders. Most drugs of abuse, including opioids, disrupt sleep....
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Comparison of intrathecal morphine and low-dose bupivacaine with intravenous morphine for postoperative analgesia in laparoscopic liver resection: a randomized controlled trial
BackgroundLaparoscopic liver surgery has undergone substantial advancements over the past few decades, and the key to this improvement has been an...
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Initiation and rapid titration of methadone and slow-release oral morphine (SROM) in an acute care, inpatient setting: a case series
BackgroundMethadone titration in an outpatient setting typically involves initiation with subtherapeutic doses with slow titration to mitigate the...
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Patient-controlled analgesia morphine for the management of acute pain in the emergency department: a systematic review and meta-analysis
BackgroundThe ideal pain control approach is typically viewed as titration of analgesia for pain reduction and periodic pain evaluation. However,...
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The 50% effective dose of hydromorphone and morphine for epidural analgesia in the hemorrhoidectomy: a double-blind, sequential dose-finding study
BackgroundAlthough previous studies have showed that epidural morphine can be used as a complement to local anesthetics for analgesia after...
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Omission of perioperative morphine reduces postoperative pain in proctological interventions: a single-center analysis
There is an increase in outpatient procedures and this trend will continue in the future. For hemorrhoidectomy, it is the standard of treatment in...
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Perioperative multimodal analgesic injection for patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion surgery
PurposeThis retrospective cohort study compared postoperative as-needed (PRN) opioid consumption pre and postimplementation of a perioperative...
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Intrathecal morphine delivery at prepontine cistern to control refractory cancer-related pain: a case report of extensive metastatic and refractory cancer pain
BackgroundExtensive metastatic and refractory cancer pain is common, and exhibits a dissatisfactory response to the conventional intrathecal infusion...
