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Molecular genetic screening of full-term small for gestational age
ObjectiveTo examine the clinical application of genomic screening in newborns small for gestational age (SGA), ho** to provide an efficient...
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Guanxin V Relieves Ventricular Remodeling by Inhibiting Inflammation: Implication from Virtual Screening, Systematic Pharmacology, Molecular Docking, and Experimental Validation
ObjectiveTo reveal the anti-inflammatory mechanism of Guanxin V, which is prescribed for ventricular remodeling in clinical practice.
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Diagnostic value of molecular approach in screening for fragile X premutation cases
BackgroundFragile X syndrome (FXS) is the most common form of inherited intellectual disability, caused by CGG-repeats expansion (> 200 repeats)....
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Virtual screening–molecular docking–activity evaluation of Ailanthus altissima (Mill.) swingle bark in the treatment of ulcerative colitis
BackgroundThe dried bark of Ailanthus altissima (Mill.) Swingle is widely used in traditional Chinese medicine for the treatment of ulcerative...
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Identification of novel AKT1 inhibitors from Sapria himalayana bioactive compounds using structure-based virtual screening and molecular dynamics simulations
Through the experimental and computational analyses, the present study sought to elucidate the chemical composition and anticancer potential of Sapria...
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A direct, sensitive and high-throughput genus and species-specific molecular assay for large-scale malaria screening
BackgroundInfectious disease diagnostics often requires sensitive molecular assays that identify at both genus and species levels. For large scale...
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Das Prostatakarzinom-Screening – aktueller Überblick
BackgroundThe harm-to-benefit ratio of prostate cancer (PCa) screening remains controversial mainly due to the unfavorable test characteristics of...
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Supplemental Screening for Breast Cancer
Purpose of ReviewIncreased breast density, among other calculated risk factors, decreases the sensitivity of screening mammography. Several...
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Screening mammographic performance by race and age in the National Mammography Database: 29,479,665 screening mammograms from 13,181,241 women
PurposeThere are insufficient large-scale studies comparing the performance of screening mammography in women of different races. This study aims to...
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A practical approach to screening for carbapenemase-producing Enterobacterales– views of a group of multidisciplinary experts from English hospitals
IntroductionCarbapenemase-producing Enterobacterales (CPE) are an important public health threat, with costly operational and economic consequences...
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Evaluation of a population-based breast cancer screening in North China
BackgroundDespite mammography-based screening for breast cancer has been conducted in many countries, there are still little data on participation...
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Virtual screening, pharmacokinetics, and molecular dynamics simulations studies to identify potent approved drugs for Chlamydia trachomatis treatment
BackgroundThe most frequent bacterial sexually transmitted disease is Chlamydia trachomatis (STD). In 2010, the Centers for Disease Control and...
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A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases
PurposeBrain metastases represent the most common intracranial tumors in adults and are associated with a poor prognosis. We used a personalized in...
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Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study
BackgroundSerological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect...
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A decade of molecular preimplantation genetic diagnosis of 350 blastomeres for beta-thalassemia combined with HLA ty**, aneuploidy screening and sex selection in Iran
BackgroundPreimplantation genetic diagnosis (PGD) has been developed to detect genetic disorders before pregnancy which is usually done on...
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Breast cancer stage and molecular subtype distribution: real-world insights from a regional oncological center in Hungary
ObjectiveExamining the distribution of breast cancer (BC) stage and molecular subtype among women aged below (< 45 years), within (45–65 years), and...
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Non-endoscopic Screening for Esophageal Squamous Cell Carcinoma: Recent Advances
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most common tumors in the gastrointestinal tract, and China has a high incidence...
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Fluorescent in situ hybridization has limitations in screening NRG1 gene rearrangements
BackgroundNRG1 fusion is a promising therapeutic target for various tumors but its prevalence is extremely low, and there are no standardized testing...
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Five-year annual incidence and clinico-molecular features of breast cancer after the last negative screening mammography at age 68–69
ObjectiveThe European Commission Initiative on Breast Cancer recommendation for triennial screening of women aged 70–74 is based on very weak...
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Comparison of phenomics and cfDNA in a large breast screening population: the Breast Screening and Monitoring Study (BSMS)
To assess their roles in breast cancer diagnostics, we aimed to compare plasma cell-free DNA (cfDNA) levels with the circulating metabolome in a...
