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Lomitapide–a Microsomal Triglyceride Transfer Protein Inhibitor for Homozygous Familial Hypercholesterolemia
Purpose of ReviewHomozygous familial hypercholesterolemia (HoFH) is a rare, genetic condition characterized by high levels of Low density lipoprotein...
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Androgens exacerbate hepatic triglyceride accumulation in rats with polycystic ovary syndrome by downregulating MTTP expression
PurposePolycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, which is closely associated with insulin resistance, glucose and...
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Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic...
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Lomitapide and Mipomersen—Inhibiting Microsomal Triglyceride Transfer Protein (MTP) and apoB100 Synthesis
Purpose of ReviewThe goal of this review is to evaluate the role of inhibiting the synthesis of lipoproteins when there is no or little residual...
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Triglyceride-Rich Lipoproteins, Remnants, and Atherosclerotic Cardiovascular Disease Risk
Purpose of ReviewTo describe seminal studies and recent reports that have focused on the metabolism and quantification of triglyceride-rich...
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Correction to: Lomitapide – a Microsomal Triglyceride Transfer Protein Inhibitor for Homozygous Familial Hypercholesterolemia
Due to errors during galley proofing, the original version of this article has been corrected.
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The Role of Phospholipid Transfer Protein in the Development of Atherosclerosis
Purpose of ReviewPhospholipid transfer protein (PLTP), a member of lipid transfer protein family, is an important protein involved in lipid...
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Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention
Despite treatment with statins, patients with elevated low-density lipoprotein cholesterol (LDL-C) and triglycerides remain at increased risk for...
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Genetics of Triglyceride-Rich Lipoproteins Guide Identification of Pharmacotherapy for Cardiovascular Risk Reduction
Objective: Despite aggressive reduction of low-density lipoprotein cholesterol (LDL-C), there is a residual risk of cardiovascular disease (CVD)....
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New CRISPR Technology for Creating Cell Models of Lipoprotein Assembly and Secretion
Purpose of ReviewThis review is aimed at providing an overview of new developments in gene editing technology, including examples of how this...
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Intestinal lipid absorption and transport in type 2 diabetes
Postprandial hyperlipidaemia is an important feature of diabetic dyslipidaemia and plays an important role in the development of cardiovascular...
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Childhood Hypertriglyceridemia: Is It Time for a New Approach?
Purpose of ReviewHypertriglyceridemia (HTG) is widely prevalent in youth. There is an unmet need for effective medications in the management of HTG...
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A Case Series Assessing the Effects of Lomitapide on Carotid Intima-Media Thickness in Adult Patients with Homozygous Familial Hypercholesterolaemia in a Real-World Setting
IntroductionHomozygous familial hypercholesterolaemia (HoFH) is characterised by extremely elevated levels of low-density lipoprotein cholesterol...
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Low LDL Cholesterol Is Not an Independent Risk Factor for Hepatic Steatosis
BackgroundGenetic mutations causing defective VLDL secretion and low LDL cholesterol are associated with hepatic steatosis and nonalcoholic fatty...
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Fumigaclavine C ameliorates liver steatosis by attenuating hepatic de novo lipogenesis via modulation of the RhoA/ROCK signaling pathway
BackgroundNon-alcoholic fatty liver disease (NAFLD) has been well defined as a common chronic liver metabolism disorder. Statins as a first-line...
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Effects of emulsifiers on lipid metabolism and performance of yellow-feathered broilers
BackgroundReducing production costs while producing high-quality livestock and poultry products is an ongoing concern in the livestock industry. The...
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Familial Chylomicronemia Syndrome (FCS): Recent Data on Diagnosis and Treatment
Purpose of ReviewFamilial chylomicronemia syndrome (FCS) is a rare recessive genetic disorder often underdiagnosed with potentially severe clinical...
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Metformin enhances LDL-cholesterol uptake by suppressing the expression of the pro-protein convertase subtilisin/kexin type 9 (PCSK9) in liver cells
PurposeMetformin (MF) intake associates with reduced levels of circulating low-density lipoprotein-cholesterol (LDL-C). This has been attributed to...
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The contribution of genetics and epigenetics to MAFLD susceptibility
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of develo** MAFLD varies among...
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Dietary choline increases brown adipose tissue activation markers and improves cholesterol metabolism in female APOE*3-Leiden.CETP mice
ObjectivesStudies in mice have recently linked increased dietary choline consumption to increased incidence of obesity-related metabolic diseases,...
