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Unveiling challenging corneal infections: a comprehensive etiological diagnosis through metagenomic next-generation sequencing (mNGS) of corneal tissue samples
PurposeThe objective of this study was to assess the clinical diagnostic value of metagenomic next-generation sequencing (mNGS) in cases of...
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Bacterial DNA metabolism analysis by metagenomic next-generation sequencing (mNGS) after treatment of bloodstream infection
BackgroundWith the advent of metagenomic next-generation sequencing (mNGS), the time of DNA metabolism can be explored after bacteria be killed. In...
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Utilizing Metagenomic Next-Generation Sequencing (mNGS) for Rapid Pathogen Identification and to Inform Clinical Decision-Making: Results from a Large Real-World Cohort
IntroductionClinical metagenomic next-generation sequencing (mNGS) has proven to be a powerful diagnostic tool in pathogen detection. However, its...
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Diagnostic performance of metagenomic next-generation sequencing for Pneumocystis jirovecii pneumonia
ObjectivePneumocystis jirovecii pneumonia (PJP) can be a life-threatening opportunistic infection. We aimed to evaluate the diagnostic accuracy of...
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The etiological diagnostic value of metagenomic next-generation sequencing in suspected community-acquired pneumonia
BackgroundThe emergence of metagenomic next-generation sequencing (mNGS) may provide a promising tool for early and comprehensive identification of...
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Clinical applications of metagenomic next-generation sequencing in the identification of pathogens in periprosthetic joint infections: a retrospective study
BackgroundThis study aimed to evaluate the application of metagenomic next-generation sequencing (mNGS) technology to identify pathogens in...
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Case report: isolated prevotella intermedia causing intracranial infection detected using metagenomic next generation sequencing
BackgroundIsolated Prevotella intermedia, a rare gram-negative, rod-shaped, anaerobic bacterium, is rarely detected in clinical practice. It has been...
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Application of metagenomic next-generation sequencing in optimizing the diagnosis of ascitic infection in patients with liver cirrhosis
BackgroundMetagenomic next-generation sequencing (mNGS) is an emerging technique for the clinical diagnosis of infectious disease that has rarely...
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Diagnostic performance of metagenomic next-generation sequencing and conventional microbial culture for spinal infection: a retrospective comparative study
PurposeThe study evaluated the diagnostic performance of metagenomic next-generation sequencing (mNGS) as a diagnostic test for biopsy samples from...
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Pathogen detection in suspected spinal infection: metagenomic next-generation sequencing versus culture
PurposeThe aim is to compare the pathogen detection performance of metagenomic next-generation sequencing (mNGS) and the culturing of percutaneous...
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Rapid diagnosis of alveolar echinococcosis from lung puncture sample using metagenomic next-generation sequencing: a case report
IntroductionAlveolar echinococcosis (AE), caused by the larval forms of Echinococcus multilocularis , is a zoonotic disease affecting the liver,...
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Metagenomic next-generation sequencing as a diagnostic tool in the clinical routine of an infectious diseases department: a retrospective cohort study
BackgroundMetagenomic next-generation sequencing (mNGS) of circulating cell-free DNA from plasma is a hypothesis-independent broadband diagnostic...
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Metagenomic next-generation sequencing for pulmonary infections diagnosis in patients with diabetes
BackgroundDiabetes mellitus is a major cause of high mortality and poor prognosis in patients with pulmonary infections. However, limited data on the...
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Metagenomic next-generation sequencing of plasma cell-free DNA improves the early diagnosis of suspected infections
BackgroundMetagenomic next-generation sequencing (mNGS) could improve the diagnosed efficiency of pathogens in bloodstream infections or sepsis....
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Application of metagenomic next-generation sequencing in the clinical diagnosis of infectious diseases after allo-HSCT: a single-center analysis
BackgroundWe investigated the value of metagenomic next-generation sequencing (mNGS) in diagnosing infectious diseases in patients receiving...
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Utilizing metagenomic next-generation sequencing for pathogen detection and diagnosis in lower respiratory tract infections in real-world clinical practice
BackgroundInfectious etiologies of lower respiratory tract infections (LRTIs) by the conventional microbiology tests (CMTs) can be challenging....
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Comparison of the diagnostic significance of cerebrospinal fluid metagenomic next-generation sequencing copy number variation analysis and cytology in leptomeningeal malignancy
BackgroundDiagnosis and monitoring of leptomeningeal malignancy remain challenging, and are usually based on neurological, radiological,...
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Comparison of metagenomic next-generation sequencing and conventional culture for the diagnostic performance in febrile patients with suspected infections
BackgroundTimely and accurate identification of pathogens is crucial for appropriate treatment and prognosis of infectious diseases. As an...
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Application of metagenomic next-generation sequencing in the diagnosis of Bartonella neuroretinitis: a case report and literature review
BackgroundCat-scratch disease (CSD) is caused by Bartonella henselae infection. In atypical cases of CSD, pathogen determination is challenging. We...
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A case report of brainstem hemorrhage due to Rhizopus delemar-induced encephalitis diagnosed by metagenomic next-generation sequencing (mNGS)
BackgroundRhizopus delemar is an invasive fungal pathogen that can cause fatal mucormycosis in immunodeficient individuals. Encephalitis caused by R....
