Search
Search Results
-
Myocardial Metabolic Reprogramming in HFpEF
AbstractHeart failure (HF) caused by structural or functional cardiac abnormalities is a significant cause of morbidity and mortality worldwide....
-
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable...
-
Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression
TNF receptor associated factor 6 (TRAF6) is an E3 ubiquitin ligase that has been implicated in myeloid malignancies. Although altered TRAF6...
-
Metabolic reprogramming in the tumor microenvironment of liver cancer
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic...
-
Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells
Radiotherapy is one of the mainstream approaches for cancer treatment, although the clinical outcomes are limited due to the radioresistance of tumor...
-
Canagliflozin regulates metabolic reprogramming in diabetic kidney disease by inducing fasting-like and aestivation-like metabolic patterns
Aims/hypothesisSodium–glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i) are antihyperglycaemic drugs that protect the kidneys of individuals with...
-
Hypoxia-induced PPFIA4 accelerates the progression of ovarian cancer through glucose metabolic reprogramming
Dysregulated glycolysis promotes growth and metastasis, which is one of the metabolic characteristics of ovarian cancer. Based on bioinformatics...
-
Lipid metabolic reprogramming mediated by circulating Nrg4 alleviates metabolic dysfunction-associated steatotic liver disease during the early recovery phase after sleeve gastrectomy
BackgroundThe metabolic benefits of bariatric surgery that contribute to the alleviation of metabolic dysfunction-associated steatotic liver disease...
-
Oncogenic metabolic reprogramming in breast cancer: focus on signaling pathways and mitochondrial genes
Oncogenic metabolic reprogramming impacts the abundance of key metabolites that regulate signaling and epigenetics. Metabolic vulnerability in the...
-
Targeting metabolic reprogramming in chronic lymphocytic leukemia
Metabolic reprogramming, fundamentally pivotal in carcinogenesis and progression of cancer, is considered as a promising therapeutic target against...
-
RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
BackgroundTriple negative breast cancer (TNBC), the most aggressive subtype of breast cancer, is characterized by a high incidence of brain...
-
Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling. Therefore,...
-
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is still an incurable disease, with many patients develo** resistance to conventional and targeted therapies. To...
-
Fusobacterium nucleatum-triggered purine metabolic reprogramming drives tumorigenesis in head and neck carcinoma
BackgroundFusobacterium nucleatum ( F. nucleatum ) is a vital pro-oncogenic bacterium. Our previous study revealed that a high abundance of F. nucleatum ...
-
UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination
Cancer cells rely on heightened protein quality control mechanisms, including the ubiquitin-proteosome system that is predominantly driven by...
-
Methyltransferase like 3 inhibition limits intrahepatic cholangiocarcinoma metabolic reprogramming and potentiates the efficacy of chemotherapy
N 6 -methyladenosine (m 6 A) RNA methylation and its associated methyltransferase like 3 (METTL3) are involved in the development and maintenance of...
-
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms
Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found that roburic acid (RBA), an ingredient...
-
The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma
In the intricate landscape of the tumor microenvironment, tumor-associated macrophages (TAMs) emerge as a ubiquitous cellular component that...
-
NF2: An underestimated player in cancer metabolic reprogramming and tumor immunity
Neurofibromatosis type 2 ( NF2 ) is a tumor suppressor gene implicated in various tumors, including mesothelioma, schwannomas, and meningioma. As a...
