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Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking
Despite established sex differences in the prevalence and presentation of psychiatric disorders, little is known about the cellular and synaptic...
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Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states
Subtype 5 metabotropic glutamate receptors (mGlu 5 ) are known to play an important role in regulating cognitive, social and valence systems. However,...
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A prospective randomised control trial to compare the perioperative outcomes and ergonomic challenges between triangular versus midline port placement in total extra-peritoneal repair of uncomplicated unilateral inguinal hernia
BackgroundRoutine TEP technique requires three skin incisions for placement of three trocars in the midline. Otherwise, this can be done by...
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Are Medical Device Characteristics Included in HTA Methods Guidelines and Reports? A Brief Review
It is well accepted that medical devices (MDs) and procedures have several unique characteristics compared with pharmaceuticals, such as learning...
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mGlu1-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice
Extensive evidence supports the hypothesis that deficits in inhibitory GABA transmission in the prefrontal cortex (PFC) may drive pathophysiological...
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Feasibility of modified-TEP technique for large inguinoscrotal and large femoral hernia and its advantages
PurposeTo describe the feasibility of modified-TEP technique in reducing dead space in large inguinoscrotal and large femoral hernia to prevent...
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Plus Sutures for preventing surgical site infection: a systematic review of clinical outcomes with economic and environmental models
BackgroundSurgical site infections (SSIs) represent ~ 20% of all hospital-acquired infections in surgical patients and are associated with prolonged...
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Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity
Adolescent alcohol exposure increases the risk of develo** alcohol use disorders (AUDs), yet the mechanisms responsible for this vulnerability...
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myCOPD App for Managing Chronic Obstructive Pulmonary Disease: A NICE Medical Technology Guidance for a Digital Health Technology
myCOPD is a digital tool designed for people to manage their chronic obstructive pulmonary disease (COPD). It requires a device with an internet...
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Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer’s disease
Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated stress response (ISR) via multiple pathologies including...
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Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the develo** somatosensory cortex
mGlu5 metabotropic glutamate receptors are highly functional in the early postnatal life, and regulate developmental plasticity of...
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Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding
Preclinical data have shown that the excitatory metabotropic Gα q -coupled glutamate receptor, mGluR5, has a role in substance abuse and relapse....
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Axonics Sacral Neuromodulation System for Treating Refractory Overactive Bladder: A NICE Medical Technologies Guidance
The Axonics sacral neuromodulation (SNM) system can be used by people with refractory overactive bladder (OAB) to reduce symptoms of urge urinary...
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The involvement of the mGluR5-mediated JNK signaling pathway in rats with diabetic retinopathy
ObjectiveTo understand the involvement of the mGluR5-mediated JNK signaling pathway in rats with diabetic retinopathy (DR).
MethodsThis study...
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Animal Models of Chronic Migraine: From the Bench to Therapy
Purpose of ReviewChronic migraine is a disabling progressive disorder without effective management approaches. Animal models have been developed and...
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Episcissors-60 for Mediolateral Episiotomy: Evaluation of Clinical and Economic Evidence to Inform NICE Medical Technologies Guidance
Obstetric anal sphincter injury (OASI) occurs in 2.9% of all vaginal births in the UK and can result in faecal incontinence. Where there is a...
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Glutamatergic Agents for the Treatment of Cocaine Use Disorder
Purpose of ReviewDisruptions in glutamate hemostasis have been implicated in cocaine use disorder (CUD). This manuscript reviews novel agents that...
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Minimally Invasive Sacroiliac Joint Fusion with Triangular Titanium Implants: Cost-Utility Analysis from NHS Perspective
ObjectiveThe aim was to identify the cost-effectiveness of minimally invasive sacroiliac joint fusion (MI SIJF) surgery with titanium triangular...
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Surrogate Endpoints in Health Technology Assessment: An International Review of Methodological Guidelines
In the drive towards faster patient access to treatments, health technology assessment (HTA) agencies are increasingly faced with reliance on...
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Assessment of Devices, Diagnostics and Digital Technologies: A Review of NICE Medical Technologies Guidance
BackgroundThe Medical Technologies Evaluation Programme (MTEP) of NICE in England aims to evaluate medical devices that are deemed to be cost-saving...
