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Distribution of tumor-infiltrating-T-lymphocytes and possible tumor-escape mechanisms avoiding immune cell attack in locally advanced adenocarcinomas of the esophagus
IntroductionThe inflammatory microenvironment has emerged as one of the focuses of cancer research. Little is known about the immune environment in...
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Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
DDR1 has been linked to schizophrenia (SCZ) and bipolar disorder (BD) in association studies. DDR1 encodes 58 distinct transcripts, which can be...
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Rhabdomyolyse durch Arzneimittelinteraktion von Atorvastatin und Cobicistat
A 53-year-old man presented with rhabdomyolysis and acute kidney injury. The symptoms were presumably caused by a drug–drug interaction between an...
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Immune checkpoint inhibitor-related myositis and myocarditis: diagnostic pitfalls and imaging contribution in a real-world, institutional case series
BackgroundImmune checkpoint inhibitors (ICIs) are resha** the prognosis of many cancers, but often cause immune-related adverse events (irAEs)....
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Effectiveness of a proteoliposome-based vaccine against salmonid rickettsial septicaemia in Oncorhynchus mykiss
Salmonid rickettsial septicaemia (SRS) is a contagious disease caused by Piscirickettsia salmonis , an intracellular bacterium. SRS causes an...
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Exosome application in tumorigenesis: diagnosis and treatment of melanoma
Melanoma is the most aggressive of skin cancer derived from genetic mutations in the melanocytes. Current therapeutic approaches include surgical...
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TEP RNA: a new frontier for early diagnosis of NSCLC
BackgroundNon-small cell lung cancer (NSCLC) is the most common type of lung cancer (LC), which is the leading cause of tumor mortality. In recent...
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Characterizing T-cell dysfunction and exclusion signatures in malignant peripheral nerve sheath tumors reveals susceptibilities to immunotherapy
PurposeMalignant peripheral nerve sheath tumors (MPNSTs) are malignant tumors that arise from peripheral nerves and are the leading cause of...
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Genetic alterations shape innate immune cells to foster immunosuppression and cancer immunotherapy resistance
Cancer immunotherapy, particularly immune checkpoint inhibitors, has opened a new avenue for cancer treatment following the durable clinical...
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Paraneoplastic neurological syndrome: growing spectrum and relevance
Paraneoplastic neurological syndromes (PNSs) are group of disorders affecting one or multiple parts of the neuroaxis associated with underlying...
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Epigenomics and immunotherapeutic advances in pediatric brain tumors
Brain tumors are the leading cause of childhood cancer-related deaths. Similar to adult brain tumors, pediatric brain tumors are classified based on...
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Miyoshi myopathy associated with spine rigidity and multiple contractures: a case report
BackgroundDysferlinopathy is a phenotypically heterogeneous group of hereditary diseases caused by mutations in the DYSF gene. Early contractures...
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Oraler Lichen planus
Oral lichen planus (OLP), a mucosal variant of lichen planus, is a frequently underestimated disease with a worldwide prevalence of 1%.
Clinically OLP...
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Comparison between adult and foetal adnexa derived equine post-natal mesenchymal stem cells
BackgroundLittle is known about the differences among adult and foetal equine mesenchymal stem cells (MSCs), and no data exist about their...
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The abscopal effect of anti-CD95 and radiotherapy in melanoma
BackgroundRadiotherapy (RT) is frequently adopted to control cancer cell proliferation, which is achieved by altering the tumor microenvironment...
