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The effects of ischaemic conditioning on lung ischaemia–reperfusion injury
Ischaemia–reperfusion injury (IRI) encompasses the deleterious effects on cellular function and survival that result from the restoration of organ...
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NR4A1 Aggravates Myocardial Ischaemia–Reperfusion Injury by Inhibiting OPA1-Mediated Mitochondrial Fusion
Mitochondrial fusion is an important process that protects the myocardium. However, mitochondrial fusion is often inhibited in myocardial...
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Inflammatory response to the ischaemia–reperfusion insult in the liver after major tissue trauma
BackgroundPolytrauma is often accompanied by ischaemia–reperfusion injury to tissues and organs, and the resulting series of immune inflammatory...
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Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity
Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by innate immunity, is one of the primary causes of early...
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Exploring the lung-gut direction of the gut-lung axis in patients with ARDS
Acute respiratory distress syndrome (ARDS) represents a life-threatening inflammatory reaction marked by refractory hypoxaemia and pulmonary oedema....
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Interorgan communication networks in the kidney–lung axis
The homeostasis and health of an organism depend on the coordinated interaction of specialized organs, which is regulated by interorgan communication...
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The Role of Extracellular DNA and Histones in Ischaemia-Reperfusion Injury of the Myocardium
Despite an increase in the rates of survival in patients suffering myocardial infarction, as yet there is no therapy specifically targeting ischaemia...
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A New Aspect of Penehyclidine Hydrochloride in Alleviating Myocardial Ischemia–Reperfusion Injury: Ferroptosis
Penehyclidine hydrochloride (PHC) is an anticholinergic drug with cardioprotective effects. Ferroptosis is closely related to myocardial...
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Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction
Following an acute myocardial infarction, reperfusion of an occluded coronary artery is often accompanied by microvascular injury, leading to worse...
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PKD2/polycystin-2 inhibits LPS-induced acute lung injury in vitro and in vivo by activating autophagy
Polycystin-2 (PC2), which is a transmembrane protein encoded by the PKD2 gene, plays an important role in kidney disease, but its role in...
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Review 2: Primary graft dysfunction after lung transplant—pathophysiology, clinical considerations and therapeutic targets
Primary graft dysfunction (PGD) is one of the most common complications in the early postoperative period and is the most common cause of death in...
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Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can...
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Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest
BackgroundCurrently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation...
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Sulfide regulation of cardiovascular function in health and disease
Hydrogen sulfide (H 2 S) has emerged as a gaseous signalling molecule with crucial implications for cardiovascular health. H 2 S is involved in many...
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Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic
Acute kidney injury (AKI) as a result of ischaemia–reperfusion represents a major healthcare burden worldwide. Mortality rates from AKI in...
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Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronically progressive fibrotic pulmonary disease characterized by an uncertain etiology, a poor...
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Epidemiology of perioperative RV dysfunction: risk factors, incidence, and clinical implications
In this edition of the journal, the Perioperative Quality Initiative (POQI) present three manuscripts describing the physiology, assessment, and...
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Review 1: Lung transplant—from donor selection to graft preparation
For various end-stage lung diseases, lung transplantation remains one of the only viable treatment options. While the demand for lung transplantation...
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Silencing of long non-coding RNA KCNQ1OT1 alleviates LPS-induced lung injury by regulating the miR-370-3p/FOXM1 axis in childhood pneumonia
PurposeLong non-coding RNAs (lncRNAs) play important roles in the development of pneumonia. We aimed to explore the role of the lncRNA KCNQ1OT1 in...
