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Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures
BackgroundEnvironmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component...
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Bone-metastatic lung adenocarcinoma cells bearing CD74-ROS1 fusion interact with macrophages to promote their dissemination
Approximately 40% of patients with lung adenocarcinoma (LUAD) often develop bone metastases during the course of their disease. However, scarcely any...
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PD-L2 overexpression on tumor-associated macrophages is one of the predictors for better prognosis in lung adenocarcinoma
Immunotherapies that target programmed cell death protein 1 (PD-1) signals are standard therapies for advanced-stage lung cancer, and the expression...
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Clinical Significance of SIRPĪ± Expression on Tumor-Associated Macrophages in Patients with Lung Squamous Cell Carcinoma
BackgroundSignal-regulatory protein alpha (SIRPĪ±) is an immune checkpoint molecule expressed on macrophages that functions to inhibit phagocytosis by...
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Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
BackgroundSystemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of skin and...
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Nesfatin-1 alleviated lipopolysaccharide-induced acute lung injury through regulating inflammatory response associated with macrophages modulation
Acute lung injury (ALI) is a continuum of lung changes associated with uncontrolled excessive lung inflammation. However, the pathogenesis of ALI is...
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Evolving polarisation of infiltrating and alveolar macrophages in the lung during metastatic progression of melanoma suggests CCR1 as a therapeutic target
Metastatic tumour progression is facilitated by tumour associated macrophages (TAMs) that enforce pro-tumour mechanisms and suppress immunity. In...
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Prognostic impact of soluble PD-L1 derived from tumor-associated macrophages in non-small-cell lung cancer
Programmed cell death-ligand 1 (PD-L1) on tumor cells can be degraded to soluble form (sPD-L1) and enter circulation, however, the clinical...
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The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma
Programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) are target molecules for immunotherapy in non-small cell lung cancer. PD-L1 is expressed not...
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Prognostic impact of the number of peri-tumoral alveolar macrophages in patients with stage I lung adenocarcinoma
PurposeIntratumoral macrophages are reportedly involved in tumor progression in non-small cell lung cancer; however, little is known about the...
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Clinicopathological significance of peritumoral alveolar macrophages in patients with resected early-stage lung squamous cell carcinoma
IntroductionThis study aimed to clarify the correlation between the number of AMs and prognosis and to examine the gene expression of AMs in lung...
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PPARĪ³ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap
BackgroundAsthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and...
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CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid
Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and...
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The roles of tissue resident macrophages in health and cancer
As integral components of the immune microenvironment, tissue resident macrophages (TRMs) represent a self-renewing and long-lived cell population...
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A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis
Tumor-associated macrophages (TAMs) are abundant in tumors and interact with tumor cells, leading to the formation of an immunosuppressive...
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Effects of electroacupuncture pretreatment on M1 polarization of alveolar macrophages in rats with acute lung injury
ObjectiveTo observe the effects of electroacupuncture (EA) pretreatment on M1 polarization of alveolar macrophages (AMs) in rats with acute lung...
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Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension
Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically...
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Macrophages in immunoregulation and therapeutics
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host...
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Immunomodulatory macrophages and Treg in pulmonary hypertension
Pulmonary hypertension (PH) is a disease that affects the right ventricle and venous circulation. The need for improvement in the discovery of novel...
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Alveolar macrophage-derived gVPLA2 promotes ventilator-induced lung injury via the cPLA2/PGE2 pathway
BackgroundVentilator-induced lung injury (VILI) is a clinical complication of mechanical ventilation observed in patients with acute respiratory...
