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Lung cancer-derived exosomal miR-132-3p contributed to interstitial lung disease development
PurposeInterstitial lung diseases (ILDs) have high morbidity and mortality and poor prognosis. The significance of microRNAs (miRNAs) was highlighted...
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Lung Function in Fontan Patients Over a Ten-Year Period: Is the Fontan Circulation Impairing Lung Development?
Few studies have investigated how the Fontan circulation affects lung function, and no studies have investigated the development of lung function...
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Leptin deficiency, a potential mechanism for impaired fetal lung development in uteroplacental insufficiency?
Uteroplacental insufficiency (UPI) is a major cause of fetal growth restriction (FGR). Leptin, an adipokine, has been shown to play a vital role in...
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Uteroplacental insufficiency decreases leptin expression and impairs lung development in growth-restricted newborn rats
BackgroundThe study aimed to analyze the effect of uteroplacental insufficiency (UPI) on leptin expression and lung development of intrauterine...
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Effects of postnatal corticosteroids on lung development in newborn animals. A systematic review
BackgroundPostnatal systemic corticosteroids reduce the risk of bronchopulmonary dysplasia but the effect depends on timing, dosing, and type of...
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Dysregulation of CITED2 in abnormal lung development in the nitrofen rat model
PurposeCITED2 both modulates lung, heart and diaphragm development. The role of CITED2 in the pathogenesis of congenital diaphragmatic hernia (CDH)...
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The effect of inhaler prescription on the development of lung cancer in COPD: a nationwide population-based study
BackgroundCOPD is associated with the development of lung cancer. A protective effect of inhaled corticosteroids (ICS) on lung cancer is still...
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Vascular and pulmonary effects of ibuprofen on neonatal lung development
BackgroundIbuprofen is a nonsteroidal anti-inflammatory drug that is commonly used to stimulate closure of a patent ductus arteriosus (PDA) in very...
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Development of a modified 3D region proposal network for lung nodule detection in computed tomography scans: a secondary analysis of lung nodule datasets
BackgroundLow-dose computed tomography (LDCT) has been shown useful in early lung cancer detection. This study aimed to develop a novel deep learning...
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Development of lung cancer risk prediction models based on F-18 FDG PET images
ObjectiveWe aimed to evaluate whether the degree of F-18 fluorodeoxyglucose (FDG) uptake in the lungs is associated with an increased risk of lung...
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Perinatal origins of bronchopulmonary dysplasia—deciphering normal and impaired lung development cell by cell
Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence of premature birth, as well as antenatal and postnatal injury...
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Effects of spinal deformities on lung development in children: a review
Scoliosis before the age of 5 years is referred to as early-onset scoliosis (EOS). While causes may vary, EOS can potentially affect respiratory...
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Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and immunity in the tumor...
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Multi-omics analysis revealed the mitochondrial-targeted drug combination to suppress the development of lung cancer
PurposeThe incidence and mortality of lung cancer are continuously rising in recent years. Mitochondrial energy metabolism malfunction is found to be...
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Development of a machine learning-based risk model for postoperative complications of lung cancer surgery
PurposeTo develop a comorbidity risk score specifically for lung resection surgeries.
MethodsWe reviewed the medical records of patients who...
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Native-lung complications following single-lung transplantation for interstitial lung disease: an in-depth analysis
BackgroundInterstitial lung disease (ILD) represents a heterogeneous group of lung disorders characterized by fibrotic lung tissue changes. In...
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Development of postoperative bronchopleural fistula after neoadjuvant immunochemotherapy in non-small cell lung cancer: case reports and review of the literature
BackgroundThe advent of immune checkpoint inhibitors has dramatically changed the treatment paradigm for advanced non-small-cell lung cancer (NSCLC)....
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External validation, radiological evaluation, and development of deep learning automatic lung segmentation in contrast-enhanced chest CT
ObjectivesThere is a need for CT pulmonary angiography (CTPA) lung segmentation models. Clinical translation requires radiological evaluation of...
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Development and Validation of txSim: A Model of Advanced Lung Cancer Treatment in Australia
Background and ObjectiveSince 2016, new therapies have transformed the standard of care for lung cancer, creating a need for up-to-date evidence for...
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Co-development of an evidence-based personalised smoking cessation intervention for use in a lung cancer screening context
BackgroundOptimising smoking cessation services within a low radiation-dose computed tomography (LDCT) lung cancer screening programme has the...
