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Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching
BackgroundConstipation was associated with incidence of dementia and cognitive decline. Laxatives are the mainstay of constipation management and are...
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Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials
The prevalence of pediatric constipation ranges from 0.7 to 29.6% across different countries. Functional constipation accounts for 95% of pediatric...
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Adherence to coprescribing of laxatives with opioids and associated characteristics in general practices in the Netherlands
BackgroundGuidelines recommend to prescribe a laxative with an opioid to prevent constipation. We aimed to determine the adherence by general...
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Prevalence of constipation and use of laxatives, and association with risk factors among older patients during hospitalization: a cross sectional study
BackgroundMany older patients experience constipation as a bothersome symptom with a negative impact on quality of life. During hospitalization, the...
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What is the Evidence for Over the Counter Laxatives to Treat Childhood Constipation?
Purpose of ReviewFunctional constipation is a common pediatric GI disorder that is responsible for a significant portion of pediatric office visits...
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Cost-Effectiveness of Linaclotide Compared to Osmotic Laxatives in the Treatment of Irritable Bowel Syndrome with Constipation in China
IntroductionLinaclotide, a selective agonist of guanylate cyclase C, was highly recommended for the treatment of irritable bowel syndrome with...
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A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer
IntroductionOpioid-induced constipation (OIC) is one of the most common side effects in patients with cancer treated with opioid analgesics. The...
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Relation between laxative use and risk of major bleeding in patients with atrial fibrillation and heart failure
Constipation has been reported to increase the risk of cardiovascular mortality. Patients with atrial fibrillation (AF) and heart failure (HF) have...
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A case of pseudo-Bartter/Gitelman syndrome caused by long-term laxative abuse, leading to end-stage kidney disease
Pseudo-Bartter/Gitelman syndrome (PBS/PGS) is a disorder that presents with hypokalemia and metabolic alkalosis resembling Gitelman syndrome (GS) due...
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Importance of Bowel Habits in Predicting Inadequate Bowel Preparation: A Prospective Observational Study
ObjectivesInadequate bowel preparation (BP) negatively affects the efficacy and quality of colonoscopy. Although constipation has already been...
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Association between anthraquinone laxatives and colorectal cancer: protocol for a systematic review and meta-analysis
IntroductionProducts containing anthraquinones (AQ) are mainly used as laxatives and have several biological effects. Long-term use of AQ laxatives...
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Factors associated with death, hospitalization, resignation, and sick leave from work among patients with schizophrenia in Japan: a nested case–control study using a large claims database
BackgroundPremature mortality, frequent relapse that easily leads to hospitalization, and discontinuous employment are key challenges for the...
