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Multisystem inflammatory syndrome in children (MIS-C) and sepsis differentiation by a clinical and analytical score: MISSEP score
Differential diagnosis between Multisystem Inflammatory Syndrome in Children (MIS-C) and other causes of systemic inflammatory response such as...
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The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice...
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A brief history of MECP2 duplication syndrome: 20-years of clinical understanding
MECP2 duplication syndrome (MDS) is a rare, X-linked, neurodevelopmental disorder caused by a duplication of the methyl-CpG-binding protein 2 ( MECP2 )...
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Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management
Multisystem inflammatory syndrome (MIS-C) is a pediatric hyperinflammation disorder caused by severe acute respiratory syndrome coronavirus-2...
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Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy
Cytokine release syndrome (CRS) embodies a mixture of clinical manifestations, including elevated circulating cytokine levels, acute systemic...
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Haemoadsorption in infective endocarditis: a systematic review
Infective endocarditis surgical patients suffer from high rates of severe complications such as systemic inflammatory response, septic shock, and...
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Environmental factors affecting pregnancy outcomes
IntroductionPregnancy represents a fragile period in the life of a woman, vulnerable to hazardous environmental substances which might affect...
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The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the leading causes of chronic liver disease worldwide. NAFLD and...
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Dermatological Manifestations of COVID-19 in Children
ContextThe clinical picture of pediatric severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection differs from adults as do the...
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Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
ObjectivesTo develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents)...
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Childhood rheumatic diseases: bites not only the joint, but also the heart
Cardiovascular involvement in juvenile rheumatic diseases is the primary manifestation in paediatric vasculitis and a major organ manifestation in...
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Reappraising the spectrum of AKI and hepatorenal syndrome in patients with cirrhosis
The occurrence of acute kidney injury (AKI) in patients with end-stage liver disease constitutes one of the most challenging clinical scenarios in...
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Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion
PurposeEndocrine disruptors exert a plethora of effects in endocrine tissues, from altered function to carcinogenesis. Given its lipophilic nature,...
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Ethylmalonic Encephalopathy: a literature review and two new cases of mild phenotype
BackgroundEthylmalonic encephalopathy (EE) is a rare intoxication-type metabolic disorder with multisystem involvement. It is caused by mutations in ETHE1...
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Serum Biomarkers in Fascial Space Infections of Odontogenic Origin and Their Role in Prognosis of Sepsis: A Systematic Review
Odontogenic infections represent a frequent cause of dental and maxillo facial interventions, mostly due to late presentations or misdiagnosed...
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Chiari type 1—a malformation or a syndrome? A critical review
ObjectiveAs the understanding of pathophysiology behind Chiari malformation still is limited, the treatment of Chiari malformation type 1 remains...
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The year 2021 in COVID-19 pandemic in children
In this article, the developments in the field of COVID-19 pandemic published in the Italian Journal of Pediatrics in 2021 are reflected. We describe...
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Do generic drugs cause hypersensitivity?
Generic drugs may differ from brand-name drugs in nature and quantity of excipients. Hypersensitivity to generic drugs is a subject of growing...
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“I’m Persephone, Queen of the Underworld”: Metramorphic swerves away from death in HBO’s Sharp Objects
In this article, I analyze HBO’s adaptation of Sharp Objects , reading it through the prism of Bracha L. Ettinger’s Demeter-Persephone complex. I...