Search
Search Results
-
Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
Despite campaigns and improvements in detection and treatment, lung cancer continues to increase worldwide and represents a major public health...
-
Kinin-kallikrein system: New perspectives in heart failure
Heart failure (HF) is a pervasive clinical challenge characterized by compromised cardiac function and reduced quality of life. The kinin-kallikrein...
-
The relationship between clinical phenotype and kallikrein-kinin bioregulation in different forms of arthritis
ObjectivePatients with rheumatoid arthritis (RA) have shown increased levels of neutrophils generating kallikrein-kinin peptides in blood which are...
-
Induction of Kallikrein-Related Peptidase 13 and TET2/3 by Anticancer Drugs and Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma After Preoperative Treatment
BackgroundPreoperative chemotherapy/chemoradiotherapy has been generally considered for the treatment of esophageal squamous cell carcinoma (ESCC) to...
-
Predictive value of kallikrein forms and β-microseminoprotein in blood from patients with evidence of detectable levels of PSA after radical prostatectomy
PurposeTo determine whether β-microseminoprotein or any of the kallikrein forms in blood-free, total or intact PSA or total hK2-predict metastasis in...
-
Decreased plasma kallikrein activity is associated with reduced kidney function in individuals with type 1 diabetes
Aims/hypothesisPlasma kallikrein is the central mediator of the plasma kallikrein–kinin system, which is involved both in vascular control and...
-
Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial
BackgroundSARS-CoV-2, the virus that causes COVID-19, enters the cells through a mechanism dependent on its binding to angiotensin-converting enzyme...
-
Hereditary Angioedema: Diagnosis, Pathogenesis, and Therapy
Purpose of ReviewThis review will focus on our current understanding of the pathogenesis of hereditary angioedema (HAE) and its therapy. HAE is...
-
Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: a link with diabetes mellitus
Early since the onset of the COVID-19 pandemic, the medical and scientific community were aware of extra respiratory actions of SARS-CoV-2 infection....
-
Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer
BackgroundHigh-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer. A growing body of evidence suggests...
-
Long-term Prophylaxis with Androgens in the management of Hereditary Angioedema (HAE) in emerging countries
Hereditary angioedema (HAE) is a rare autosomal dominant genetic disease characterized by repetitive subcutaneous or submucosal angioedema,...
-
Tumor-derived KLK8 predicts inferior survival and promotes an immune-suppressive tumor microenvironment in lung squamous cell carcinoma
Lung squamous cell carcinoma (LUSC) is the second most common lung cancer worldwide, leading to millions of deaths annually. Although immunotherapy...
-
Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
IntroductionImmunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often develo** gastrointestinal and renal...
-
A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time
Background(p-BthTX-I) 2 K, a dimeric analog peptide derived from the C-terminal region of phospholipase A2-like bothropstoxin-I (p-BthTX-I), is...
-
Kallikrein-Related Peptidase mRNA Expression in Adenoid Cystic Carcinoma of Salivary Glands: A Polymerase Chain Reaction Study
Kallikrein-related peptidases (KLKs) are a group of 15 serine proteases implicated in a variety of biological processes. Aberrant expression of KLKs ...
-
Hereditary Angioedema: Diagnosis, Clinical Implications, and Pathophysiology
Hereditary angioedema (HAE) is an autosomal dominant disorder caused by a mutation in the C1 esterase inhibitor gene. HAE affects 1/50,000 people...
-
Efficacy and Safety of Garadacimab in Combination with Standard of Care Treatment in Patients with Severe COVID-19
BackgroundGaradacimab, a fully human IgG4 monoclonal antibody, inhibits the kallikrein–kinin pathway at a key initiator, activated coagulation factor...
-
The kallikrein-like activity of Heloderma venom is inhibited by carbon monoxide
Lizards in the genus Heloderma are the most ancient venomous reptiles, with a traceable lineage nearly 100 million years old. The proteome of the...
