Search
Search Results
-
Kinin-kallikrein system: New perspectives in heart failure
Heart failure (HF) is a pervasive clinical challenge characterized by compromised cardiac function and reduced quality of life. The kinin-kallikrein...
-
Molecular Dambusters: What Is Behind Hyperpermeability in Bradykinin-Mediated Angioedema?
In the last few decades, a substantial body of evidence underlined the pivotal role of bradykinin in certain types of angioedema. The formation and...
-
Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
Despite campaigns and improvements in detection and treatment, lung cancer continues to increase worldwide and represents a major public health...
-
Risk factors for long-term survival in patients with ypN+ M0 rectal cancer after radical anterior resection
BackgroundRegional lymph node metastases are the main adverse prognostic factor in patients with rectal cancer without distant metastases. There are...
-
Sex differences in carcinoid syndrome: A gap to be closed
The incidence of neuroendocrine neoplasms and related carcinoid syndrome (CS) has markedly increased over the last decades and women seem to be more...
-
Innate immunity in diabetic kidney disease
Increasing evidence suggests that renal inflammation contributes to the pathogenesis and progression of diabetic kidney disease (DKD) and that...
-
Blood Clotting and the Pathogenesis of Types I and II Hereditary Angioedema
The plasma contact system is the initiator of the intrinsic pathway of coagulation and the main producer of the inflammatory peptide bradykinin. When...
-
Effects of Transcatheter Arterial Microembolization on Persistent Trapezius Myalgia Refractory to Conservative Treatment
PurposeTo evaluate the safety and efficacy of transcatheter arterial microembolization for patients with trapezius myalgia.
Materials and Methods ...
-
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
BackgroundIn this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia...
-
Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis
BackgroundKinins are short peptides with a wide range of proinflammatory properties that are generated from kininogens in the so-called...
-
2020 update on the renin–angiotensin–aldosterone system in pediatric kidney disease and its interactions with coronavirus
The last decade was crucial for our understanding of the renin–angiotensin–aldosterone system (RAAS) as a two-axis, counter-regulatory system,...
-
A gender-specific association of the polymorphism Ile197Met in the kininogen 1 gene with plasma irbesartan concentrations in Chinese patients with essential hypertension
This study was conducted to explore interactions in the association of the kininogen (KNG1) Ile197Met polymorphism and gender with plasma...
-
Should ACE inhibitors and ARBs be used in combination in children?
The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in a host of renal and cardiovascular functions. Angiotensin-converting enzyme...
-
Traumatic optic neuropathy treatment trial (TONTT): open label, phase 3, multicenter, semi-experimental trial
PurposeIntravenously administered erythropoietin (EPO) was firstly commenced (phase 1) in patients with indirect traumatic optic neuropathy (TON) by...
-
-
Potential Expanded Indications for Neprilysin Inhibitors
Purpose of ReviewThe goal of this article is to review potential expanded indications for neprilysin inhibitors. This article reviews the rationale...
-
Long-term neprilysin inhibition — implications for ARNIs
Neprilysin has a major role in both the generation and degradation of bioactive peptides. LCZ696 (valsartan/sacubitril, Entresto), the first of the...
-
Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes
BackgroundDespite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been repeatedly reported as an independent positive...
