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Pimecrolimus 1% cream for mild-to-moderate atopic dermatitis: a systematic review and meta-analysis with a focus on children and sensitive skin areas
This systematic literature review (SLR) and meta-analysis assessed the efficacy and safety of pimecrolimus vs other topical treatments in patients...
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Pregnancy Benefit of Acupuncture on in vitro Fertilization: A Systematic Review and Meta-Analysis
BackgroundCurrently, more and more infertility couples are opting for combined acupuncture to improve success rate of in vitro fertilization (IVF)....
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Topical Tranexamic Acid: Risks, Benefits and Novel Complications in Aesthetic Plastic Surgery
AbstractAntifibrinolytics, particularly tranexamic acid (TXA), are agents used to reduce bleeding. TXA is a synthetic reversible competitive...
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Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke
The Coronavirus disease 2019 (COVID-19) epidemic has triggered a huge impact on healthcare, socioeconomics, and other aspects of the world over the...
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Unraveling the complex roles of macrophages in obese adipose tissue: an overview
Macrophages, a heterogeneous population of innate immune cells, exhibit remarkable plasticity and play pivotal roles in coordinating immune responses...
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Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan (Liver) Depression and Qi Stagnation Syndrome: A Randomized, Double-Blind, Multi-Center, Phase-II Clinical Trial
ObjectiveTo confirm the efficacy and safety of Ganyushu Granule (GYSG) in treating premenstrual syndrome (PMS) in patients with Gan (Liver)...
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Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors
The internal tandem duplication (ITD) mutation of the FMS-like receptor tyrosine kinase 3 ( FLT3-ITD ) is the most common mutation observed in...
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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges
Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challenge owing to scarce treatment alternatives....
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The Application of Deep Brain Stimulation for Parkinson’s Disease on the Motor Pathway: A Bibliometric Analysis across 10 Years
Background and ObjectiveSince its initial report by James Parkinson in 1817, Parkinson’s disease (PD) has remained a central subject of research and...
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Pathological progression of osteoarthritis: a perspective on subchondral bone
Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global aging population has led to a surge in OA cases, thereby...
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Multivariate longitudinal data for survival analysis of cardiovascular event prediction in young adults: insights from a comparative explainable study
BackgroundMultivariate longitudinal data are under-utilized for survival analysis compared to cross-sectional data (CS - data collected once across...
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Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients
Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder. FAP54 , the homolog of CFAP54 in Chlamydomonas reinhardtii ,...
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Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurogenerative disorder with uncertain origins. Emerging evidence implicates N6-methyladenosine...
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Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of...
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Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis: A Multi-center, Double-Blinded and Randomized Controlled Trial
ObjectiveTo assess the efficacy and safety of Bufei Jiedu (BFJD) ranules as adjuvant therapy for patients with multidrug-resistant pulmonary...
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Base editors: development and applications in biomedicine
Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system with an individual deaminase, enabling precise single-base...