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Evaluating the clinical impact of routine whole genome sequencing in tuberculosis treatment decisions and the issue of isoniazid mono-resistance
BackgroundThe UK has implemented routine use of whole genome sequencing (WGS) in TB diagnostics. The WHO recommends addition of a fluoroquinolone for...
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Diagnostic accuracy of the Xpert® MTB/XDR assay for detection of Isoniazid and second-line antituberculosis drugs resistance at central TB reference laboratory in Tanzania
IntroductionEarly diagnosis of tuberculosis (TB) and universal access to drug-susceptibility testing (DST) are critical elements of the WHO End TB...
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Treatment outcomes of retreated patients with isoniazid/rifampicin resistant pulmonary tuberculosis
BackgroundAbout 8% of TB cases worldwide are estimated to have rifampicin-susceptible, isoniazid-resistant tuberculosis (Hr-TB), ranging from 5 to...
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Accurate and affordable detection of rifampicin and isoniazid resistance in Tuberculosis sputum specimens by multiplex PCR-multiple probes melting analysis
BackgroundEscalating cases of multidrug-resistant tuberculosis (MDR-TB) pose a major challenge to global TB control efforts, necessitating innovative...
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Incidence and Patterns of Drug Resistance in Patients with Spinal Tuberculosis: a Prospective, Single-Center Study from a Tuberculosis-Endemic Country
BackgroundThere is paucity of data on incidence and pattern of drug resistance in spinal TB. This prospective observational study was conducted to...
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Xpert MTB/XDR assay: rapid TB drug resistance detection
PurposeTo assess the Xpert MTB/XDR assay’s efficiency in promptly detecting resistance to isoniazid, fluoroquinolones, ethionamide, and second-line...
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Association between Mycobacterium tuberculosis genotype and diabetes mellitus/hypertension: a molecular study
BackgroundA paucity of studies focused on the genetic association that tuberculosis (TB) patients with non-communicable diseases (NCDs) are more...
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Association between body mass index and newly diagnosed drug-resistant pulmonary tuberculosis in Shandong, China from 2004 to 2019
BackgroundDrug-resistant tuberculosis (DR-TB), obesity, and malnutrition are growing public health problems in the world. However, little has...
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Estimating tuberculosis drug resistance amplification rates in high-burden settings
BackgroundAntimicrobial resistance develops following the accrual of mutations in the bacterial genome, and may variably impact organism fitness and...
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The differences in drug resistance between drug-resistant tuberculosis patients with and without diabetes mellitus in northeast China: a retrospective study
BackgroundDiabetes mellitus (DM) and drug-resistant tuberculosis (DR-TB) are serious global public health problems. This study aimed to explore the...
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Phenotypic drug susceptibility characterization and clinical outcomes of tuberculosis strains with A-probe mutation by GeneXpert MTB/RIF
BackgroundGeneXpert MTB/RIF (Xpert) assay was applied widely to detect Mycobacterium tuberculosis (MTB) and rifampicin resistance.
Methods ...
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Factors associated with isoniazid resistant tuberculosis among human immunodeficiency virus positive patients in Swaziland: a case-control study
BackgroundIsoniazid resistant tuberculosis is the most prevalent type of resistance in Swaziland and over two-thirds of the isoniazid resistant...
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Evaluation of the broth microdilution plate methodology for susceptibility testing of Mycobacterium tuberculosis in Peru
BackgroundTuberculosis (TB) is a communicable, preventable and curable disease caused by the bacterium Mycobacterium tuberculosis (MTB). Peru is...
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Comparison of GeneXpert and line probe assay for detection of Mycobacterium tuberculosis and rifampicin-mono resistance at the National Tuberculosis Reference Laboratory, Kenya
BackgroundThe dual challenge of low diagnostic sensitivity of microscopy test and technical challenge of performing a TB culture test poses a problem...
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Molecular characterisation of second-line drug resistance among drug resistant tuberculosis patients tested in Uganda: a two and a half-year’s review
BackgroundSecond-line drug resistance (SLD) among tuberculosis (TB) patients is a serious emerging challenge towards global control of the...
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Spectrum of Drug Resistance in Musculoskeletal Tuberculosis
BackgroundVery few studies report resistance pattern exclusively in musculoskeletal tuberculosis (MSK-TB).
MethodsThis study of 100 pus samples from...
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Trends in the availability and prices of quality-assured tuberculosis drugs: a systematic analysis of Global Drug Facility Product Catalogs from 2001 to 2024
BackgroundThe Global Drug Facility (GDF) of the Stop TB Partnership was launched in 2001 with the goal of increasing access to quality-assured...
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Bedaquiline safety, efficacy, utilization and emergence of resistance following treatment of multidrug-resistant tuberculosis patients in South Africa: a retrospective cohort analysis
BackgroundThis retrospective cohort study assessed benefits and risks of bedaquiline treatment in multidrug-resistant-tuberculosis (MDR-TB)...
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Age-stratified anti-tuberculosis drug resistance profiles in South Korea: a multicenter retrospective study
BackgroundThe emergence of drug-resistant tuberculosis (DR-TB) is a major healthcare concern worldwide. Here, we analyzed age-related trends in DR-TB...
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High resolution melting assay as a reliable method for diagnosing drug-resistant TB cases: a systematic review and meta-analysis
BackgroundTuberculosis (TB) is one of the most contagious infectious diseases worldwide. Currently, drug-resistant Mycobacterium tuberculosis ( Mtb )...
