Search
Search Results
-
Inhibition of Slc39a14/Slc39a8 reduce vascular calcification via alleviating iron overload induced ferroptosis in vascular smooth muscle cells
BackgroundVascular calcification (VC) is an independent risk factor for cardiovascular diseases. Recently, ferroptosis has been recognised as a novel...
-
Iron Overload and Anemia in Rhesus Hemolytic Disease of Newborn: A Prospective Observational Study
This study assessed the prevalence of iron overload in infants born to Rh isoimmunized mothers. Infants born to Rh isoimmunized mothers with Indirect...
-
Ferroptosis: a new target for iron overload-induced hemophilic arthropathy synovitis
Iron deposition is closely related to develo** haemophilic arthropathy (HA). Studying the relationship between ferroptosis signal expression and...
-
Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis
Iron overload associated cardiac dysfunction remains a significant clinical challenge whose underlying mechanism(s) have yet to be defined. We aim to...
-
Feasibility and performance of spin-echo EPI MR elastography at 3 Tesla for staging hepatic fibrosis in the presence of hepatic iron overload
PurposeTo assess the feasibility and performance of MR elastography (MRE) for quantifying liver fibrosis in patients with and without hepatic iron...
-
Aquaporin 4 Mediates the Effect of Iron Overload on Hydrocephalus After Intraventricular Hemorrhage
BackgroundIron overload plays an important role in hydrocephalus development following intraventricular hemorrhage (IVH). Aquaporin 4 (AQP4)...
-
Evaluation of iron overload in visceral organs in thalassemia patients by point shear-wave elastography
IntroductionThe aim of this study was to investigate the value of point shear-wave elastography (pSWE) in the measurement of iron overload in the...
-
TFR1 knockdown alleviates iron overload and mitochondrial dysfunction during neural differentiation of Alzheimer’s disease-derived induced pluripotent stem cells by interacting with GSK3B
Iron metabolism disorders are implicated in the pathogenesis of Alzheimer’s disease (AD). It was previously reported that transferrin receptor (TFR1)...
-
Association of hepatic/pancreatic iron overload evaluated by quantitative T2* MRI with bone mineral density and trabecular bone score
BackgroundIron-overloaded patients are recognized as presenting an increased risk of osteoporosis. However, studies on the correlation between...
-
Role of cardiac magnetic resonance T1 map** in comparison to T2* for cardiac iron overload assessment in transfusion-dependent thalassemia major patients
BackgroundCardiac complications are the leading cause of death in transfusion-dependent thalassemia major (TDT) patients due to increased cardiac...
-
Vitamin D levels and left ventricular function in beta-thalassemia major with iron overload
Heart disease is the primary cause of death in patients with beta-thalassemia major. The study aimed to determine the association between vitamin D...
-
Evaluating renal iron overload in diabetes mellitus by blood oxygen level-dependent magnetic resonance imaging: a longitudinal experimental study
BackgroundIron overload plays a critical role in the pathogenesis of diabetic nephropathy. Non-invasive evaluation of renal iron overload in diabetes...
-
Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice
Iron overload (IOL) is hypothesized to contribute to dysplastic erythropoiesis. Several conditions, including myelodysplastic syndrome, thalassemia...
-
Epidemiological and transcriptome data identify potential key genes involved in iron overload for type 2 diabetes
BackgroundMany previous studies have reported the association between iron overload (IO) and type 2 diabetes mellitus (T2DM). However, the underlying...
-
Revisiting iron overload status and change thresholds as predictors of mortality in transfusion-dependent β-thalassemia: a 10-year cohort study
Data on iron overload status and change thresholds that can predict mortality in patients with transfusion-dependent β-thalassemia (TDT) are limited....
-
Roxadustat and transfusional iron overload induced hypothyroidism in a hemodialysis patient: a case report with a literature review
BackgroundAlthough roxadustat has been reported to cause central hypothyroidism, the details of the mechanisms and clinical characteristics of...
-
Roux-en-Y Gastric Bypass as a Treatment for Hepatic Iron Overload: An Exploratory Study
BackgroundExcess bodily iron content is commonly associated with obesity and metabolic associated medical conditions and is thought to lead to...
-
Increased myocardial extracellular volume is associated with myocardial iron overload and heart failure in thalassemia major
ObjectivesMyocardial extracellular volume (ECV) by cardiovascular magnetic resonance (CMR) is a surrogate marker of diffuse fibrosis. We evaluated...
-
Left ventricular global function index is associated with myocardial iron overload and heart failure in thalassemia major patients
Purpose: The left ventricular global function index (LVGFI) is a comprehensive marker of cardiac performance, integrating LV morphology with global...
