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Intestinal Barrier Dysfunction in Inflammatory Bowel Disease: Underpinning Pathogenesis and Therapeutics
The intestinal barrier is composed of several essential elements including luminal enzymes, bile acids, water layer, epithelial layer, and enterocyte...
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Sexual, urinary, and intestinal dysfunction after rectal surgery: pre-, intra-, and post-operative predictors and trends over time in a single high-volume center
The incidence of long-term complications after rectal surgery varies widely among studies, and data regarding functional sequelae after transanal...
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Rifaximin Prevents Intestinal Barrier Dysfunction and Alleviates Liver Injury in MCT-induced HSOS Mice
ObjectiveRifaximin is an effective component of treatment strategies for liver and intestinal diseases. However, the efficacy of rifaximin in hepatic...
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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1
ObjectiveTo investigate the effect of honokiol (HON) and the role of high-mobility group protein B1 (HMGB1) on the pathogenesis of severe acute...
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Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn’s disease
BackgroundDisrupted intestinal epithelial barrier is one of the major causes of Crohn’s disease (CD). Novel molecular targets for intestinal...
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Research progress on intestinal microbiota regulating cognitive function through the gut-brain axis
The intestinal microbiota community is a fundamental component of the human body and plays a significant regulatory role in maintaining overall...
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Research on the mechanism of prednisone in the treatment of ITP via VIP/PACAP-mediated intestinal immune dysfunction
RationaleImmune thrombocytopenia (ITP) is thought to be a result of immune dysfunction, which is treated by glucocorticoids such as prednisone....
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Berberine alleviates ischemia reperfusion injury induced AKI by regulation of intestinal microbiota and reducing intestinal inflammation
BackgroundIt has been found that a variety of host disease states can exacerbate intestinal inflammation, leading to disruption of intestinal barrier...
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Intestinal and Extra-intestinal Complications of Typhoid Fever: an Update
Purpose of ReviewTyphoid fever is one of the commonest global health burdens and has various local and systemic complications. The clinical picture...
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Small intestinal mucosal abnormalities using video capsule endoscopy in intestinal lymphangiectasia
BackgroundIntestinal lymphangiectasia (IL) is a rare protein-losing enteropathy caused by disorders of the intestinal lymphatics. There are only a...
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Intestinal disturbances associated with mortality of children with complicated severe malnutrition
BackgroundChildren admitted to hospital with complicated severe malnutrition (CSM) have high mortality despite compliance with standard WHO...
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Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer
BackgroundInflammation is known to be an essential driver of various types of cancer. An increasing number of studies have suggested that the...
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Electroacupuncture Improving Intestinal Barrier Function in Rats with Irritable Bowel Syndrome Through Regulating Aquaporins
BackgroundIntestinal mucosal barrier dysfunction plays a crucial role in the pathogenesis of irritable bowel syndrome with diarrhea (IBS-D). In order...
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Epithelial CRL4DCAF2 Is Critical for Maintaining Intestinal Homeostasis Against DSS-Induced Colitis by Regulating the Proliferation and Repair of Intestinal Epithelial Cells
Background and AimsInflammatory bowel disease (IBD) is currently gaining an increasing global interest. Intestinal epithelial barrier dysfunction is...
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Ameliorative Effects of Larazotide Acetate on Intestinal Permeability and Bacterial Translocation in Acute Pancreatitis Model in Rats
BackgroundIntestinal barrier dysfunction in acute pancreatitis (AP) may progress to systemic inflammatory response syndrome (SIRS) and multi-organ...
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Reassessing acquired neonatal intestinal diseases using unsupervised machine learning
BackgroundAcquired neonatal intestinal diseases have an array of overlap** presentations and are often labeled under the dichotomous classification...
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Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case–control study
BackgroundImpaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream...
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Intestinal Microbiota in Sepsis
Sepsis is defined as a life-threatening organ dysfunction, which is caused by a dysregulated host response to infection. The composition of the...
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Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis
BackgroundNecrotizing enterocolitis (NEC) is an often-lethal disease of the premature infant intestinal tract, exacerbated by significant diagnostic...
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Thyroid dysfunction due to trace element deficiency—not only selenium but also zinc
IntroductionLevels of serum selenium (Se) and zinc (Zn) decrease when total parental nutrition (TPN) is administered without trace element...
